Fear relapse: neural substrates underlying its inhibition and prevention

恐惧复发：其抑制和预防的神经基质

• 批准号: nhmrc : 1061705
• 负责人: Dr Vincent Laurent
• 金额: $ 29.17万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fear-relapse-neural-inhibition-prevention/454919
• 关键词: Fear; relapse; neural; substrates; underlying

Exposure-based therapies are effective for anxiety disorders such as post traumatic stress, but two challenges remain: 1) patients that have learned to inhibit their fear are likely to relapse, requiring further therapy; 2) many drop out of therapy since it is aversive and anxiety provoking. We use an animal model to: 1) identify the neural substrates underlying fear inhibition; and 2) determine the conditions that prevent relapse and encourage participation in treatment.

暴露疗法对创伤后应激等焦虑症是有效的，但仍然存在两个挑战：1)已经学会抑制恐惧的患者可能会复发，需要进一步治疗；2)许多人退出了治疗，因为它令人厌恶和焦虑。我们使用动物模型：1)识别恐惧抑制的神经基质；2)确定防止复发和鼓励参与治疗的条件。