Modelling post-traumatic stress disorder in rats: hypervigilance and spread of fear

模拟大鼠创伤后应激障碍：过度警惕和恐惧蔓延

• 批准号: nhmrc : 1146999
• 负责人: Dr Vincent Laurent
• 金额: $ 23.55万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modelling-post-traumatic-spread-fear/1320775
• 关键词: Modelling; post; traumatic; stress; disorder

Post-traumatic stress disorder is characterized by hypervigilance and spread of fear across a network of trauma related memories. The consequences of hypervigilance for information processing, and the mechanisms involved in the spread of fear, are unknown. This project uses animal models to identify these consequences and mechanisms, and their substrates in the brain. It examines how a network of trauma related memories can be erased, and thus, how core symptoms of the disorder may be treated.

创伤后应激障碍的特征是过度警惕和恐惧在创伤相关记忆网络中的传播。过度警觉对信息处理的影响，以及恐惧传播的机制，都是未知的。该项目使用动物模型来识别这些后果和机制，以及它们在大脑中的底物。它研究了如何消除与创伤相关的记忆网络，以及如何治疗这种疾病的核心症状。