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Using ecophysiology to better predict the uptake of chemicals into fish

利用生态生理学更好地预测鱼类对化学物质的吸收

基本信息

批准号：
2695320
负责人：
金额：
--
依托单位：
UNIVERSITY OF EXETER
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2695320
关键词：
Using ecophysiology better predict uptake

项目摘要

Freshwater chemistry varies greatly, e.g. H+ and calcium by >1,000-fold depending on location, which majorly influence chemical speciation and properties of gills and skin that affect chemical uptake. This mechanistic project will fill this knowledge gap to allow ecological risk assessment to be tailored to match regional conditions. Our multidisciplinary supervisory team provides world-class expertise in physiology, ecotoxicology, and analytical chemistry to support the student in this truly novel project. The transepithelial electrical potential (TEP) across aquatic animal gills/skin influences uptake of charged molecules, but is dramatically influenced (e.g. from -35 to +10 mV) by natural variability in freshwater chemistry (e.g. pH, Ca, salinity, DOC). How TEP affects chemical uptake represents a major knowledge gap in ecotoxicology and may explain large inconsistencies in their uptake between individual fish and different studies.The student will develop expertise in in vivo and in vitro physiology experimentation with fish and cell cultures, including measuring transepithelial electrical potential (TEP) across gills and chemical uptake in a range of species. We will provide training in skills relevant to analytical chemistry and understanding chemical speciation, and statistical and modelling methods.

淡水的化学成分差异很大，例如，H+和钙的含量因地点而异，相差1，000倍以上，这主要影响化学形态以及鳃和皮肤的特性，从而影响化学吸收。这一机械项目将填补这一知识空白，使生态风险评估能够适应区域条件。我们的多学科监督团队提供生理学，生态毒理学和分析化学方面的世界一流专业知识，以支持学生参与这个真正新颖的项目。跨水生动物鳃/皮肤的跨上皮电位（TEP）影响带电分子的摄取，但受淡水化学（例如pH、Ca、盐度、DOC）的自然变化的显著影响（例如从-35到+10 mV）。TEP如何影响化学品的吸收代表了生态毒理学的一个主要知识缺口，并可能解释个别鱼类和不同研究之间的吸收存在很大的不一致性。学生将在鱼和细胞培养物的体内和体外生理学实验中发展专业知识，包括测量跨鳃的跨上皮电位（TEP）和一系列物种的化学品吸收。我们将提供与分析化学和理解化学形态，统计和建模方法相关的技能培训。