Effect of Thyroid Hormone on Parameters of Hypercoagulab

甲状腺激素对高凝参数的影响

• 批准号: 7004836
• 负责人: mcdonald k horne
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7004836
• 关键词: blood chemistry; blood coagulation disorders; clinical research; coagulation factor VIII; fibrinolysis; hormone regulation /control mechanism; human subject; plasminogen activator inhibitors; prothrombin; thyroid hormones

Because of an increased incidence of thromboembolic disease associated with thyroiditis, thyroid hormone has been suspected of impacting the normal thrombohemorrhagic balance. However, the effect of the hormone has never been studied in the absence of inflammatory thyroid disease. We have isolated the effect of thyroid hormone by studying it in patients with a history of thyroid cancer who had had total thyroidectomies. Blood samples were obtained from these patients when they were taking suppressive doses of thyroxin and were therefore chemically hyperthyroid and again after they had discontinued their replacement in order to have a I131 thyroid scan and were chemically very hypothyroid. A series of analytes related to coagulability and fibrinolysis were measured. We found that when the patients were hyperthyroid they had elevated levels of prothrombin fragment F1+2, factor VIII, and plasminogen activator inhibitor-1, all of which suggest that thyroid hormone is prothrombotic. This work has been completed and is in press.

由于与甲状腺炎相关的血栓栓塞性疾病的发病率增加，甲状腺激素被怀疑影响正常的血栓出血平衡。然而，在没有炎症性甲状腺疾病的情况下，从未研究过这种激素的作用。我们通过对有甲状腺癌病史并做过甲状腺全切除术的患者进行研究，分离出甲状腺激素的作用。当这些患者服用抑制剂量的甲状腺素时，从他们那里获得血液样本，因此化学甲状腺功能亢进，在他们停止替代品后再次获得血液样本，以便进行I131甲状腺扫描，化学甲状腺功能非常低下。测定了一系列与凝血和纤溶相关的分析物。我们发现，当患者甲状腺功能亢进，他们有凝血酶原片段F1+2，因子VIII和纤溶酶原激活物抑制剂-1的水平升高，所有这些都表明，甲状腺激素是促血栓形成。这项工作已经完成，正在印刷中。