Effect of Thyroid Hormone on Parameters of Hypercoagulab

由于与甲状腺炎相关的血栓栓塞性疾病的发生率增加，甲状腺激素被怀疑影响正常的血栓出血平衡。然而，在没有炎症性甲状腺疾病的情况下，这种激素的作用从未被研究过。我们通过对有甲状腺癌病史的患者进行甲状腺全切除术的研究，分离出了甲状腺激素的作用。血样是在这些患者服用抑制剂量的甲状腺素时采集的，因此是化学上的甲状腺机能亢进，在他们为了进行I131甲状腺扫描而停止替代治疗后再次采集，化学上是非常低的甲状腺功能。测定了一系列与凝血和纤溶有关的分析物质。我们发现甲亢患者的凝血酶原片段F1+2、凝血因子VIII和纤溶酶原激活物抑制物-1水平升高，提示甲状腺激素是促血栓形成的。这项工作已经完成，正在进行中。

Because of an increased incidence of thromboembolic disease associated with thyroiditis, thyroid hormone has been suspected of impacting the normal thrombohemorrhagic balance. However, the effect of the hormone has never been studied in the absence of inflammatory thyroid disease. We have isolated the effect of thyroid hormone by studying it in patients with a history of thyroid cancer who had had total thyroidectomies. Blood samples were obtained from these patients when they were taking suppressive doses of thyroxin and were therefore chemically hyperthyroid and again after they had discontinued their replacement in order to have a I131 thyroid scan and were chemically very hypothyroid. A series of analytes related to coagulability and fibrinolysis were measured. We found that when the patients were hyperthyroid they had elevated levels of prothrombin fragment F1+2, factor VIII, and plasminogen activator inhibitor-1, all of which suggest that thyroid hormone is prothrombotic. This work has been completed and is in press.