Pharmacokinetics of Pulse-Sprayed TPA
Pharmacokinetics of Pulse-Sprayed TPA
批准号:
7004838
负责人:
mcdonald k horne
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$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
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未结题
起止时间:
至
中文摘要
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英文摘要
For several years we have been treating deep vein thrombosis with recombinant tissue plasminogen activator that is injected directly into the clots. We have now collected blood samples before and at several time points following the treatment to determine how long the drug has a systemic effect. We found that it only circulates in an active form for 1 - 2 hours after injection and then becomes inhibited by a rise in plasminogen activator inhibitor-1. This work has now been published.
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