Effect Of Epinephrine In A Canine Model Of Septic Shock

肾上腺素在犬感染性休克模型中的作用

• 批准号: 6993976
• 负责人: Steven Solomon
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6993976
• 关键词: blood pressure; cardiac output; chemotherapy; disease /disorder model; dogs; dosage; drug screening /evaluation; epinephrine; experimental designs; nonhuman therapy evaluation; norepinephrine; septic shock; therapy design /development; vasoconstrictors

Early in the development of sepsis, the combined cardiopulmonary and peripheral effects result in a decreased blood pressure, reduced ability to maintain blood pressure in the periphery and normal to increased blood pumped out of the heart. In non-survivors, end-stage septic shock is characterized by a low blood pressure and a reduced ability to pump blood out of the heart resulting in multiple organ system failure and death. The inability to resolve the heart dysfunction and maintain adequate blood flow to the organs is the most significant contributing factor to the demise of the patient. Treatment of patients with sepsis consists of giving fluids and vasopressors to maintain blood pressure while giving antibiotics to kill the bacteria. At present, the canine model of sepsis uses a bacterial clot and is treated with fluids and antibiotics. The purpose of this study is to determine the number of animals necessary to determine the dose of epinephrine that will maintain blood pressure during sepsis and if this will have a beneficial effect on outcome. The use of epinephrine should allow us to more accurately characterize the treatment of sepsis in humans and address the low blood pressure and cardiac output.

在脓毒症发展的早期，心肺和外周的联合作用导致血压下降，维持外周血压的能力下降，心脏泵出的血液正常到增加。在非幸存者中，终末期感染性休克的特点是低血压和泵血能力下降，导致多器官系统衰竭和死亡。不能解决心功能障碍和维持足够的血液流向器官是导致患者死亡的最重要因素。脓毒症患者的治疗包括给予液体和血管加压剂以维持血压，同时给予抗生素以杀死细菌。目前，犬类败血症模型使用细菌凝块，并使用液体和抗生素治疗。本研究的目的是确定在脓毒症期间维持血压的肾上腺素剂量所需的动物数量，以及这是否会对结果产生有益的影响。肾上腺素的使用应该使我们能够更准确地描述人类败血症的治疗特征，并解决低血压和心输出量问题。

项目成果

Sympathetic blockade in a canine model of gram-negative bacterial peritonitis.

革兰氏阴性细菌性腹膜炎犬模型中的交感神经阻滞。

• DOI: 10.1097/00024382-200303000-00004
• 发表时间: 2003
• 期刊: Shock (Augusta, Ga.)
• 作者: Solomon,StevenB;Banks,StevenM;Gerstenberger,Eric;Csako,Gyorgy;Bacher,JohnD;Thomas3rd,MarvinL;Costello,Rene;Eichacker,PeterQ;Danner,RobertL;Natanson,Charles
• 通讯作者: Natanson,Charles