Understanding glial cell sensing and shape changing feedback during morphogenesis by integrating simulations and in vivo zebrafish experiments

通过整合模拟和体内斑马鱼实验来了解形态发生过程中神经胶质细胞的感知和形状变化的反馈

• 批准号: 2723170
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2723170
• 关键词: Understanding; glial; cell; sensing; shape

Cells in developmental morphogenesis require feedback from their environment to findtheir correct positions and establish functional shapes. The processes are challengingto understand in vivo so this project will integrate simulations to provide essentialexplanatory power to untangle the complex feedback. The Bentley laboratory areexpert in developing predictive cell simulations and the MacDonald lab are in vivoexperts understanding glial cells, the support cells of the nervous system. In order toconduct their many supportive functions for neurons, glial cells must be positionedcorrectly amongst the synaptic connections, but how glial cells achieve this remains tobe explored.

发育形态发生中的细胞需要来自环境的反馈来找到正确的位置并建立功能形状。这些过程在体内很难理解，因此该项目将整合模拟，以提供必要的解释力来理清复杂的反馈。 Bentley 实验室是开发预测细胞模拟的专家，MacDonald 实验室是了解神经胶质细胞（神经系统的支持细胞）的体内专家。为了对神经元发挥许多支持功能，神经胶质细胞必须正确定位在突触连接之间，但神经胶质细胞如何实现这一点仍有待探索。