MGH Large Animal Program Improvements

MGH 大型动物计划的改进

• 批准号: 6906094
• 负责人: RICHARD F BRINGHURST
• 金额: $ 62.45万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2008-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6906094
• 关键词: Primates; anesthesia; anesthetics; animal colony; biomedical facility; community; health; hospitals; housing; intensive care; lighting; medicine; monitoring device; occupational health /safety; pathology; postmortem; radiology; surgery; surgery material /equipment; ultrasound

DESCRIPTION (provided by applicant): The overall goals of the animal care and use program of the Massachusetts General Hospital (MGH) are to meet the needs of the institution's biomedical research community and its collaborators by 1) providing high quality laboratory animals of known health status and background; 2) providing animal husbandry and veterinary services in a functional viviarium; 3) assuring compliance of all animal- and occupational safety-related regulations and guidelines; and 4) maintaining a knowledgeable, compassionate and customer-responsive work force at all levels. The department at MGH that is responsible for animal husbandry, veterinary care, and other usual tasks is the Center for Comparative Medicine and Laboratory Animal Services (CCM). To meet these goals and accommodate an increasing number of research protocols requiring intensive and sophisticated veterinary care, greater security surveillance, and specialized caging, MGH is upgrading its large animal research capabilities and facilities. The specific aims of this submission are: 1. To improve pre- and peri-operative anesthesia during surgery and similar procedures, through the use of updated anesthesia equipment, anesthetic monitoring devices and surgery equipment (lights, tables, etc.). 2. To improve post-operative monitoring and support through the use of modem intensive care units and defibrillators. 3. To improve veterinary diagnostics by procuring clinical pathology analyzers, digital radiology, ultrasound, and necropsy equipment. 4. To assure a high level of security by installing digital surveillance cameras in all hallways and entrances to the large animal facility. 5. To enhance large animal, in particular nonhuman primate, housing with paired housing caging and additional environmental enrichment. 6. To update equipment used for handling conscious nonhuman primates to enhance animal welfare, minimize adverse effects on research data, and ensure personnel safety.

描述（由申请人提供）： 马萨诸塞州综合医院（MGH）的动物护理和使用计划的总体目标是满足该机构的生物医学研究社区及其合作者的需求，以提供1）提供已知健康状况和背景的高质量实验室动物； 2）在功能性的植物中提供畜牧业和兽医服务； 3）确保所有动物和职业安全有关的法规和准则的遵守； 4）在各个层面上保持知识渊博，富有同情心和客户响应的劳动力。负责畜牧业，兽医护理和其他常规任务的MGH部门是比较医学和实验室动物服务中心（CCM）。为了实现这些目标并适应越来越多的研究方案，需要密集，复杂的兽医护理，更大的安全监视和专门的笼子，MGH正在升级其大型动物研究能力和设施。此提交的具体目的是：1。通过使用更新的麻醉设备，麻醉器监测设备和手术设备（灯，桌子等），通过使用更新的麻醉设备，改善手术前和围手术期麻醉。 2。通过使用调制解调器重症监护装置和除颤器来改善术后监测和支持。 3。通过采购临床病理分析仪，数字放射学，超声和死灵的设备来改善兽医诊断。 4。通过在所有走廊和大型动物设施的入口处安装数字监视摄像机来确保高度安全。 5。为了增强大型动物，尤其是非人类的灵长类动物，带有配对的外壳笼子和额外的环境富集。 6。更新用于处理有意识的非人类灵长类动物以增强动物福利的设备，请最大程度地减少对研究数据的不利影响，并确保人员安全。