Animal Biosafety Level 3 Telemetry Infrastructure

动物生物安全 3 级遥测基础设施

• 批准号: 10192114
• 负责人: Peter Gordon Barr-Gillespie
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10192114
• 关键词: Aging; Anesthesia procedures; Anesthetics; Animals; Area; Assisted Reproductive Technology; Behavioral; Bioinformatics; Biomedical Research; Biometry; Blood Pressure; Businesses; COVID-19 pandemic; Cardiac; Clinical Medicine; Communicable Diseases; Communities; Data; Development; Devices; Endocrine; Environment; Exposure to; Flow Cytometry; Funding; Genetic; Goals; Grant; Health; Health Sciences; Health Services Research; Human; Immunology; Implant; Infectious Agent; Infectious Diseases Research; Information Systems; Infrastructure; Institution; Japanese Monkey; Libraries; Logistics; Magnetic Resonance Imaging; Measures; Mentors; Modeling; Modernization; Molecular; Molecular Virology; Neurosciences; Obesity; Oregon; Pathology; Physiological; Pre-Clinical Model; Prevention; Primates; Request for Applications; Research; Research Personnel; Research Support; Resources; Risk; Safety; Science; Services; System; Technology; Telemetry; Temperature; Therapeutic; Training; Training and Education; Translational Research; United States National Institutes of Health; Universities; animal care; animal data; base; biosafety level 3 facility; cardiometabolism; design; high risk; high standard; human disease; improved; infrastructure development; model development; next generation; nonhuman primate; operation; outreach; pandemic disease; programs; reproductive; respiratory; stem; surgical service; systems research; vaccine development

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC), located on the West Campus of Oregon Health & Science University (OHSU), requests funds to renew grant P51--OD011092 for the next five--year period (May 1, 2019--April 30, 2024). Currently in its 59th year of operation, the ONPRC has served a broad range of local, regional, and national investigators performing biomedical research in nonhuman primate (NHP) models with the goal of improving human health. The goals for the next funding period are reflected in the following Specific Aims: 1) Conduct state--of--the--art research that advances understanding of causes and the development of preventions, treatments, and cures for debilitating human diseases; 2) Provide exceptional NHP expertise and services to researchers at the local, regional, and national levels to advance NIH-- and other federally-- supported research programs; 3) Pursue the highest standards of humane and responsible animal care; and 4) Mentor and train the next generation of translational NHP researchers and educate the public about the importance of biomedical research. To accomplish these aims, support is requested in seven broad areas. These areas are: (1) Administration, which provides the administrative and service support required for all aspects of the ONPRC (Governance, Director's Office, Business Services, Facilities, Improvements and Modernization, Information Systems, Research Library, and Research Safety); (2) Animal Services [Resources & Logistics, Operations, Pathology Services, Surgical Services, Behavioral Services, Education and Training, Clinical Medicine, and NHP Resources (Obese, Aging, Infectious Disease, and Japanese Macaque)] ; (3) Core Science Services [Research Cores (Assisted Reproductive Technologies, Bioinformatics & Biostatistics, Endocrine Technologies, Flow Cytometry, Integrated Pathology, Molecular Technologies, Molecular Virology, Magnetic Resonance Imaging (MRI), and Primate Genetics)] ; (4) Scientific Components, including support for Scientific Divisions (Cardiometabolic Health, Genetics, Neuroscience, Pathobiology & Immunology, and Reproductive & Developmental Sciences); (5) Pilot Research Program; (6) Outreach and Community Engagement; and (7) NPRC Consortium--Based Activities. ONPRC's overarching goal is to develop, study, and share NHP models that can inform the causes of human diseases, leading to better preventions, treatments, and cures. The ONPRC achieves this goal by supporting translational research and expertise in models that are provided locally, regionally, and nationally on a collaborative basis. The host institution, OHSU, recognizes the ONPRC as one of the university's `top five' strengths and has pledged to continue support for programmatic integration and infrastructure development.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC），位于俄勒冈州健康与健康学院西校区 科学大学（OHSU），要求资金更新补助金P51-OD 011092为未来五年期间（5月 1，2019- 2024年4月30日）。目前，在其第59个年头的运作，ONPRC已服务于广泛的地方， 在非人灵长类动物（NHP）模型中进行生物医学研究的区域和国家研究者， 改善人类健康的目标。下一个供资期的目标反映在以下具体目标中： 目标：1）进行国家- 预防、治疗和治愈使人衰弱的疾病; 2）提供卓越的NHP专业知识， 为地方、地区和国家层面的研究人员提供服务，以促进NIH和其他联邦机构的发展， 支持的研究计划; 3）追求人道和负责任的动物护理的最高标准;和4） 指导和培训下一代翻译NHP研究人员，并教育公众 生物医学研究的重要性。为了实现这些目标，需要在七个广泛领域提供支助。 这些领域是：（1）行政，为所有人提供所需的行政和服务支持 ONPRC的各个方面（治理、董事办公室、商业服务、设施、改进和 现代化、信息系统、研究图书馆和研究安全）;（2）动物服务[资源 &后勤，运营，病理学服务，外科服务，行为服务，教育和培训， 临床医学和NHP资源（肥胖、衰老、传染病和日本猕猴）] ;（3）核心 科学服务[研究核心（辅助生殖技术、生物信息学和生物统计学、 内分泌技术，流式细胞术，综合病理学，分子技术，分子病毒学， 磁共振成像（MRI）和灵长类遗传学）] ;（4）科学组件，包括支持 科学部门（心脏代谢健康，遗传学，神经科学，病理生物学和免疫学， 生殖与发育科学）;（5）试点研究计划;（6）外展和社区 （7）NPRC财团-基于活动。 ONPRC的首要目标是开发，研究和分享NHP模型，可以告知人类疾病的原因。 疾病，导致更好的预防，治疗和治愈。ONPRC通过支持实现这一目标 在当地，区域和国家提供的模型中的转化研究和专业知识， 合作的基础。主办机构OHSU承认ONPRC是该大学的“前五名”之一 联合国教科文组织已承诺继续支持方案整合和基础设施发展。