DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

描述(由申请人提供)： 维克森林大学医学院(WFUSM)计划其研究项目的未来增长。为了支持这一增长，该机构四个校区中的两个已经在建设或计划建设新的动物收容所。未来几年，建设新的研究空间将需要大量的机构投资。在与华盛顿国家灵长类动物研究中心(WaNPRC)的合作下，我们建议利用WFUSM可用的繁殖空间来容纳WaNPRC的繁殖群体，以生产无特定病原体(SPF)的婴儿，以支持生物医学界的研究需求。WaNPRC正在提交一份同时进行的P40申请，题为“WaNPRC-WFUSM猕猴SPF繁育群体”。由于NHP已知短缺，这些应用程序如果获得资金，将解决SPF猴子研究对象严重短缺的问题。这项提案要求资金：1)修改现有的畜栏，以提供更多可用的群养母羊畜栏，以及2)提供设备，以更好地照顾婴儿。G20的这一申请和WaNPRC的P40申请代表了一种具有成本效益和独特资格的伙伴关系，以满足预计将持续很长时间的国家需求。仅在WFUSM，这些改进将直接影响39名研究人员的研究，他们目前持有1220万美元的外部资助项目(年度直接成本)，以及17名研究人员申请740万美元(年度直接成本)的未决项目。如果获得资金，这项申请将为WaNPRC和WFUSM提供一种机制，以经济高效地使用现有资源，利用各自在非人类灵长类繁殖和群体管理方面的互补专业知识，并准备帮助支持新的国家倡议和已经成功的研究项目。

DESCRIPTION (provided by applicant): The Wake Forest University School of Medicine (WFUSM) projects future growth of its research programs. To support this growth, construction of new animal housing space is already underway or planned on two of the institution's four campuses. Construction of new research space will require considerable institutional investment over the next few years. In collaboration with the Washington National Primate Research Center (WaNPRC), we propose to utilize WFUSM available breeding space to house breeding colonies from WaNPRC to produce specific pathogen free (SPF) infants to support research needs for the biomedical community. A concurrent P40 application is being submitted by WaNPRC, entitled "WaNPRC-WFUSM Macaca fascicularis SPF Breeding Colony". As there is a known shortage of NHP, these applications, if funded, would address a critical shortage of need for SPF monkey research subjects. This proposal requests funds to: 1) modify existing corrals to provide more usable group harem breeding corrals, and 2) provide equipment for better infant care. This G20 application and the P40 application from WaNPRC represent a cost-effective and uniquely qualified partnership to address a national need that is projected to continue well into the future. At WFUSM alone, these improvements will directly impact the research of 39 investigators who currently hold $12.2 million (annual direct costs) in externally funded projects, and 17 investigators who have applied for $7.4 million (annual direct costs) in pending projects. If funded, this application will provide a mechanism for WaNPRC and WFUSM to cost-effectively use existing resources, take advantage of each group's complementary expertise in nonhuman primate breeding and colony management, and be poised to help support new national initiatives and already successful research programs.