Kidney and Cardiovascular Disease in American Indians

美洲印第安人的肾脏和心血管疾病

• 批准号: 7109541
• 负责人: Nawar Shara
• 金额: $ 5.34万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109541
• 关键词: Native Americans; biomarker; cardiovascular disorder; cardiovascular disorder epidemiology; epidemiology; glomerular filtration rate; guanine; health disparity; human data; human tissue; kidney disorder; lipid peroxides; oxidative stress; pathologic process; postdoctoral investigator; prostaglandin F

DESCRIPTION (provided by applicant): Renal dysfunction and abnormalities of the cardiovascular system often occur simultaneously and may share common pathophysiology. Factors influencing progression of one disease state are thought to influence progression of the other. The Strong Heart Study (SHS) provides a unique opportunity to study changes in renal function, CVD risk factors, subclinical CVD as well as clinical events in American Indians (AI). AI are a health disparity population due to their extremely high rates of diabetes and diabetic complications. I propose to (1) perform secondary data analyses to examine the co-progression of renal and cardiovascular disease in AI in the SHS and (2) conduct a pilot study involving measurement of oxidative stress markers in relation to progression of renal and cardiovascular disease in AI. Specifically, I propose to conduct a series of cross-sectional, survival and repeated measures analyses involving glomerular filtration rate and measures of clinical (Ml, CHD) and subclinical (carotid atherosclerosis, echocardiography) cardiovascular disease to better define the co-progression of renal and CVD in AI. Further, I propose to conduct a pilot study of CVD cases and controls in which I will use stored specimens from the SHS to examine levels of F2-isoprostane and 8- hydroxyguanine, two markers of oxidative stress. Achievement of these aims, along with the other training activities described in this application, and the structured mentoring offered by Drs. Resnick and Umans will provide me with the skills, knowledge and direction that will help me begin developing a research program focused in health disparities in renal disease. My long term professional objective is to develop a funded research program dealing with renal disease in minority populations.

描述（由申请人提供）：肾功能障碍和心血管系统异常经常同时发生，并且可能具有共同的病理生理学。影响一种疾病状态进展的因素被认为会影响另一种疾病状态的进展。强心脏研究 (SHS) 提供了一个独特的机会来研究美洲印第安人 (AI) 的肾功能变化、CVD 危险因素、亚临床 CVD 以及临床事件。由于糖尿病和糖尿病并发症的发病率极高，人工智能是一个健康差异群体。我建议（1）进行二次数据分析，以检查 SHS 中 AI 中肾脏和心血管疾病的共同进展，以及（2）进行一项试点研究，涉及测量与 AI 中肾脏和心血管疾病进展相关的氧化应激标志物。具体来说，我建议进行一系列横断面、生存和重复测量分析，涉及肾小球滤过率以及临床（MI、CHD）和亚临床（颈动脉粥样硬化、超声心动图）心血管疾病的测量，以更好地定义 AI 中肾脏和 CVD 的共同进展。此外，我建议对 CVD 病例和对照进行一项试点研究，其中我将使用 SHS 保存的样本来检查 F2-异前列烷和 8-羟基鸟嘌呤（两种氧化应激标志物）的水平。这些目标的实现，以及本申请中描述的其他培训活动，以及博士提供的结构化指导。雷斯尼克和乌曼斯将为我提供技能、知识和方向，帮助我开始制定一个专注于肾脏疾病健康差异的研究项目。我的长期专业目标是制定一项资助的研究计划，以应对少数群体的肾脏疾病。