Hot Flash Ambulatory Monitor

描述(由申请人提供)：潮热的范围从非常恼人的分心到令人衰弱的情况，75%或更多的绝经后妇女经历过这种情况。尽管已经提出了许多治疗方案，但大多数治疗方法都有很大的风险，或者很少或几乎没有有效的科学证据。皮肤电导已被认为是潮热的唯一最佳客观检测方法。拟议的工作将产生一种改进的临床工具，用于检测和记录潮热。这款新设备将比现有技术更小、更多功能，最重要的是，当旁观者佩戴时，它几乎看不见。建议的设备将使用皮肤电导检测和记录潮热发生，并通过用户激活按钮记录用户感知的潮热。额外的传感器将与皮肤电导测量一起工作，将进一步提高热闪测量的可靠性。该计划将测试这些额外的传感器在提高热闪检测的灵敏度或阳性预测性或增加检测相对热闪强度和持续时间方面的有效性和成本效益。在这个项目结束时，研究人员将可以使用一个新的工具来客观地验证热潮红治疗方案。

DESCRIPTION (provided by applicant): Hot flashes range from very annoying distraction to debilitating condition for the 75% or more post- menopausal women that experience them. Although many treatment options have been proposed, most of these treatments have significant risks or little to no scientific proof of effectiveness. Skin conductance has been identified as the single best objective detection of hot flashes. The proposed work will produce an improved clinical tool for detection and recording of hot flashes. This new device will be smaller and more versatile than the existing technology and most importantly virtually invisible to a bystander when being worn. The proposed device will detect and record hot-flash occurrences using skin conductance and also record user perceived hot flashes through a user activated button. Additional sensors that will work in conjunction with skin conductance measurement will further improve the reliability of hot flash measurement. This program will test each of these additional sensors for their efficacy and cost effectiveness in improving sensitivity or positive predictivity of hot flash detection, or the addition of detecting relative hot flash intensity and duration. At the end of this program, a new tool will be available to researchers for objectively validating hot flash treatment options.