Submicron Particles and Fibers for Toxicological Studies

用于毒理学研究的亚微米颗粒和纤维

• 批准号: 6932875
• 负责人: GUSTAVO Fabian LARSEN
• 金额: $ 20.61万
• 依托单位: LNKCHEMSOLUTIONS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-05 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932875
• 关键词: biomaterial development /preparation; community health services; environmental health; laboratory rabbit; metal oxide; nanotechnology; occupational health /safety; particle; pesticides; plant poisons; toxicology

DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by the increasing level of concern among policy makers, Federal agencies, academic researchers and the general public regarding the toxicity of new nanomaterials. We are convinced that our initiative is timely, and that it responds a true societal need. The proposed business venture is based on a unique set of manufacturing methods to design a wide variety of well-defined nanostructured powders, and a partnership with the Midwest Research Institute is established to integrate toxicology tests with the nanomanufacturing component, and into a business plan involving professionals with diverse backgrounds. The proposed effort also involves participation of Kamterter II, LLC, another Lincoln, NE based small business with an interest in nanotechnology applications for the agrochemical industry. LNKChemsolutions will contribute the know-how for nanomaterials synthesis. The MRI has code-compliant barrier facilities to handle the more toxic samples, and a proven track record of research with animal models. Kamterter II, LLC, provides a platform to target the agrochemical secdtor, who is becoming increasingly more concerned with the formulation, use, and environmental impact of pesticides in their nanoparticulate forms. Preliminary toxicology tests on three model systems with real commercial potential, and the design of such nanostructured materials, will serve as a platform to launch a spinoff business venture dedicated to serving the health sciences community and the private sector concerned with the environmental and occupational health impact of new nanotechnology products. The three case studies will include nanoparticle synthesis and preliminary toxicological testing of one metal oxide, one pesticide, and one multiactivity phytochemical. On completion of Phase I research, we expect to appeal to a broad clientele for custom synthesis of well-defined and characterized nanomaterials for toxicological evaluation, or for contract research and testing.

描述（由申请人提供）：第一阶段 SBIR 计划旨在启动一家致力于生产用于毒理学研究的纳米颗粒的企业。商业、学术和私营部门纳米技术研发的增长速度似乎只落后于政策制定者、联邦机构、学术研究人员和公众对新纳米材料毒性的日益关注。我们相信，我们的举措是及时的，并且它满足了真正的社会需求。 拟议的企业基于一套独特的制造方法来设计各种明确的纳米结构粉末，并与中西部研究所建立了合作伙伴关系，将毒理学测试与纳米制造组件结合起来，并纳入涉及具有不同背景的专业人士的商业计划中。拟议的工作还包括 Kamterter II, LLC 的参与，这是另一家位于内布拉斯加州林肯市的小企业，对农化行业的纳米技术应用感兴趣。 LNKChemsolutions 将贡献纳米材料合成的专业知识。 MRI 拥有符合规范的屏障设施，可以处理毒性较大的样本，并拥有经过验证的动物模型研究记录。 Kamterter II, LLC 提供了一个针对农化行业的平台，该行业越来越关注纳米颗粒农药的配方、使用和环境影响。 对具有真正商业潜力的三个模型系统进行初步毒理学测试，以及此类纳米结构材料的设计，将作为一个平台来启动一个衍生企业，致力于为健康科学界和关注新纳米技术产品对环境和职业健康影响的私营部门提供服务。这三个案例研究将包括一种金属氧化物、一种农药和一种多活性植物化学物质的纳米颗粒合成和初步毒理学测试。第一阶段研究完成后，我们希望吸引广大客户定制合成明确且表征的纳米材料，以进行毒理学评估或合同研究和测试。