Submicron Particles and Fibers for Toxicological Studies

描述（由申请人提供）：该第一阶段SBIR计划旨在启动一项专门用于毒理学研究的纳米颗粒制造的商业企业。商业、学术和私营部门的纳米技术研发增长率似乎只被政策制定者、联邦机构、学术研究人员和公众对新纳米材料毒性的日益关注所超过。我们相信，我们的倡议是及时的，它回应了真正的社会需要。 拟议的商业企业是基于一套独特的制造方法来设计各种各样的定义明确的纳米结构粉末，并建立了与中西部研究所的合作伙伴关系，将毒理学测试与纳米制造组件，并纳入一个涉及不同背景的专业人士的商业计划。拟议的努力还涉及Kamterter II，LLC的参与，另一个林肯，NE为基础的小企业与纳米技术应用的农业化学工业的兴趣。LNKChemsolutions将为纳米材料合成贡献专业知识。MRI具有符合规范的屏障设施，以处理毒性更大的样本，以及经过验证的动物模型研究记录。Kamterter II，LLC提供了一个平台，以针对农用化学品部门，谁是越来越多地关注农药的配方，使用和环境影响，在其纳米颗粒形式。 对具有真实的商业潜力的三个模型系统进行初步毒理学测试，并设计这种纳米结构材料，将作为一个平台，启动一个附带的商业企业，致力于为健康科学界和私营部门提供服务，关注新纳米技术产品对环境和职业健康的影响。这三个案例研究将包括纳米颗粒合成和一种金属氧化物，一种农药和一种多活性植物化学品的初步毒理学测试。在第一阶段研究完成后，我们希望吸引广泛的客户，为毒理学评估或合同研究和测试定制合成定义明确和表征的纳米材料。

DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by the increasing level of concern among policy makers, Federal agencies, academic researchers and the general public regarding the toxicity of new nanomaterials. We are convinced that our initiative is timely, and that it responds a true societal need. The proposed business venture is based on a unique set of manufacturing methods to design a wide variety of well-defined nanostructured powders, and a partnership with the Midwest Research Institute is established to integrate toxicology tests with the nanomanufacturing component, and into a business plan involving professionals with diverse backgrounds. The proposed effort also involves participation of Kamterter II, LLC, another Lincoln, NE based small business with an interest in nanotechnology applications for the agrochemical industry. LNKChemsolutions will contribute the know-how for nanomaterials synthesis. The MRI has code-compliant barrier facilities to handle the more toxic samples, and a proven track record of research with animal models. Kamterter II, LLC, provides a platform to target the agrochemical secdtor, who is becoming increasingly more concerned with the formulation, use, and environmental impact of pesticides in their nanoparticulate forms. Preliminary toxicology tests on three model systems with real commercial potential, and the design of such nanostructured materials, will serve as a platform to launch a spinoff business venture dedicated to serving the health sciences community and the private sector concerned with the environmental and occupational health impact of new nanotechnology products. The three case studies will include nanoparticle synthesis and preliminary toxicological testing of one metal oxide, one pesticide, and one multiactivity phytochemical. On completion of Phase I research, we expect to appeal to a broad clientele for custom synthesis of well-defined and characterized nanomaterials for toxicological evaluation, or for contract research and testing.