Submicron Particles and Fibers for Toxicological Studies

描述(由申请者提供)：这个第一阶段的SBIR项目旨在启动一家致力于生产用于毒理学研究的纳米颗粒的商业企业。商业、学术和私营部门的纳米技术研发增长速度似乎只超过了政策制定者、联邦机构、学术研究人员和公众对新纳米材料毒性的日益关注。我们相信，我们的倡议是及时的，它回应了真正的社会需求。 拟议的商业合资企业基于一套独特的制造方法，以设计各种定义良好的纳米结构粉末，并与中西部研究所建立了合作伙伴关系，将毒理学测试与纳米制造组件整合在一起，并将其纳入涉及不同背景的专业人员的商业计划中。拟议的工作还包括Kamterter II，LLC的参与，这是另一家总部位于东北林肯的小企业，对农业化学工业的纳米技术应用感兴趣。LNK化学解决方案将为纳米材料的合成贡献技术诀窍。核磁共振成像拥有符合法规的屏障设施来处理毒性更大的样本，并且有经过验证的动物模型研究记录。Kamterter II，LLC提供了一个针对农化部门的平台，后者越来越关注纳米形式农药的配方、使用和对环境的影响。 对三个真正具有商业潜力的模型系统进行初步毒理学测试，以及这些纳米结构材料的设计，将作为一个平台，启动一个剥离的商业企业，致力于服务于关注新纳米技术产品对环境和职业健康影响的健康科学界和私营部门。这三个案例研究将包括一种金属氧化物、一种杀虫剂和一种多活性植物化学物质的纳米颗粒合成和初步毒理学测试。在完成第一阶段研究后，我们预计将吸引更多的客户，为毒理学评估或合同研究和测试定制合成明确定义和表征的纳米材料。

DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by the increasing level of concern among policy makers, Federal agencies, academic researchers and the general public regarding the toxicity of new nanomaterials. We are convinced that our initiative is timely, and that it responds a true societal need. The proposed business venture is based on a unique set of manufacturing methods to design a wide variety of well-defined nanostructured powders, and a partnership with the Midwest Research Institute is established to integrate toxicology tests with the nanomanufacturing component, and into a business plan involving professionals with diverse backgrounds. The proposed effort also involves participation of Kamterter II, LLC, another Lincoln, NE based small business with an interest in nanotechnology applications for the agrochemical industry. LNKChemsolutions will contribute the know-how for nanomaterials synthesis. The MRI has code-compliant barrier facilities to handle the more toxic samples, and a proven track record of research with animal models. Kamterter II, LLC, provides a platform to target the agrochemical secdtor, who is becoming increasingly more concerned with the formulation, use, and environmental impact of pesticides in their nanoparticulate forms. Preliminary toxicology tests on three model systems with real commercial potential, and the design of such nanostructured materials, will serve as a platform to launch a spinoff business venture dedicated to serving the health sciences community and the private sector concerned with the environmental and occupational health impact of new nanotechnology products. The three case studies will include nanoparticle synthesis and preliminary toxicological testing of one metal oxide, one pesticide, and one multiactivity phytochemical. On completion of Phase I research, we expect to appeal to a broad clientele for custom synthesis of well-defined and characterized nanomaterials for toxicological evaluation, or for contract research and testing.