Novel Nanofiber-reinforced All-ceramic Dental Materials

新型纳米纤维增强全瓷牙科材料

• 批准号: 6694209
• 负责人: GUSTAVO Fabian LARSEN
• 金额: $ 10万
• 依托单位: LNKCHEMSOLUTIONS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694209
• 关键词: aluminum oxide; bioengineering /biomedical engineering; biomaterial development /preparation; ceramics; dental materials; glass; magnesium; metal oxide; nanotechnology; zirconium

DESCRIPTION: Novel continuous, non-woven oxide nanofibers will be used to design, produce and test a new class of allceramic materials for restorative Dental applications. The working hypothesis is that these new nanofiber/glass systems will be of significantly higher mechanical quality than state-of-the-art technologies used in the field. Two materials scientists (Drs. Dzenis and Larsen, co-PI and PI, respectively) will collaborate with a faculty member from the College of Medicine, University of Nebraska Medical Center (external consultant, Dr. Thomas Salinas) during Phase I. One of the current topics of emphasis in allceramic restorations research is on developing reliable large-span posterior fixed partial dentures (FPDs). This will be one of the central product development areas that the proposed technology will target toward the commercialization phase. The proposed R and D effort is in line with the mission and current strategic research areas of the National Institute of Dental and Craniofacial Research (NIDCR). It is anticipated that the novel glass-infiltrated materials will have excellent crack propagation resistance thanks to dense and continuous fibrous reinforcing scaffolds based on alumina, spinel, zirconia, mullite, or a combination of them to produce Dental ceramics with superior esthetic and mechanical qualities. During Phase I, emphasis will be on production of the first few, selected nanofiber-glass materials of this class, their mechanical testing (e.g., flexural strength and fracture toughness), and their microstructure characterization (e.g., porosity and defect population).

描述：新型连续、非织造氧化物纳米纤维将用于设计、生产和测试用于修复牙科应用的新型全陶瓷材料。工作假设是，这些新的纳米纤维/玻璃系统的机械质量将明显高于该领域使用的最先进技术。两位材料科学家（分别为联合 PI 和 PI 的 Dzenis 博士和 Larsen 博士）将与内布拉斯加大学医学中心医学院的一名教员（外部顾问 Thomas Salinas 博士）在第一阶段合作。目前全瓷修复体研究的重点主题之一是开发可靠的大跨度后牙固定局部义齿 (FPD)。这将是拟议技术进入商业化阶段的核心产品开发领域之一。拟议的研发工作符合国家牙科和颅面研究所 (NIDCR) 的使命和当前战略研究领域。预计，由于基于氧化铝、尖晶石、氧化锆、莫来石或其组合的致密且连续的纤维增强支架，新型玻璃渗透材料将具有优异的抗裂纹扩展性能，从而生产出具有卓越美学和机械品质的牙科陶瓷。在第一阶段，重点将放在生产首批选定的此类纳米玻璃纤维材料、其机械测试（例如弯曲强度和断裂韧性）及其微观结构表征（例如孔隙率和缺陷数量）。