Submicron Particles and Fibers for Toxicological Studies

用于毒理学研究的亚微米颗粒和纤维

• 批准号: 7120156
• 负责人: GUSTAVO Fabian LARSEN
• 金额: $ 17.01万
• 依托单位: LNKCHEMSOLUTIONS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-05 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120156
• 关键词: biomaterial development /preparation; community health services; environmental health; laboratory rabbit; metal oxide; nanotechnology; occupational health /safety; particle; pesticides; plant poisons; toxicology

DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by the increasing level of concern among policy makers, Federal agencies, academic researchers and the general public regarding the toxicity of new nanomaterials. We are convinced that our initiative is timely, and that it responds a true societal need. The proposed business venture is based on a unique set of manufacturing methods to design a wide variety of well-defined nanostructured powders, and a partnership with the Midwest Research Institute is established to integrate toxicology tests with the nanomanufacturing component, and into a business plan involving professionals with diverse backgrounds. The proposed effort also involves participation of Kamterter II, LLC, another Lincoln, NE based small business with an interest in nanotechnology applications for the agrochemical industry. LNKChemsolutions will contribute the know-how for nanomaterials synthesis. The MRI has code-compliant barrier facilities to handle the more toxic samples, and a proven track record of research with animal models. Kamterter II, LLC, provides a platform to target the agrochemical secdtor, who is becoming increasingly more concerned with the formulation, use, and environmental impact of pesticides in their nanoparticulate forms. Preliminary toxicology tests on three model systems with real commercial potential, and the design of such nanostructured materials, will serve as a platform to launch a spinoff business venture dedicated to serving the health sciences community and the private sector concerned with the environmental and occupational health impact of new nanotechnology products. The three case studies will include nanoparticle synthesis and preliminary toxicological testing of one metal oxide, one pesticide, and one multiactivity phytochemical. On completion of Phase I research, we expect to appeal to a broad clientele for custom synthesis of well-defined and characterized nanomaterials for toxicological evaluation, or for contract research and testing.

描述（由申请人提供）：该I期SBIR项目旨在启动一个致力于制造用于毒理学研究的纳米颗粒的商业企业。只有决策者、联邦机构、学术研究人员和普通公众对新型纳米材料的毒性越来越关注，才会超过商业、学术和私营部门纳米技术研发的增长速度。我们相信，我们的倡议是及时的，它回应了真正的社会需要。