Nano-Apatite Coating of the Porous Surface of Implants

植入物多孔表面的纳米磷灰石涂层

• 批准号: 6882306
• 负责人: CHITTARANJAN P SINGH
• 金额: $ 17.41万
• 依托单位: NANO INTERFACE TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2007-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882306
• 关键词: X ray crystallography; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biotechnology; carbonates; corrosions; cost effectiveness; dental prosthesis; hip prosthesis; hydroxyapatites; infrared spectrometry; joint prosthesis; knee; mechanical stress; medical implant science; nanotechnology; orthopedics; surface coating; surface property; titanium

DESCRIPTION (provided by applicant): The rate of hip replacement has increased to 21% in the last five years. The proportion of hip or knee replacement procedures that needed revision remained in between 16% and 17%. The cemented total hip replacement is normally preferred but cemented implants have only 10-12 years of life span. The osteolysis caused by the fragments of the cement and corrosion in the implants are main reason of the failure of the prosthesis. A number of studies have revealed better biocompatibility and effectiveness of hydroxyapatite-coated implants. The use of poor quality of starting material and the high temperature attained during the plasma-sprayed coatings are the major source of impurities in the hydroxyapatite-coated implants. This leads to weaker bond strength of the coatings, delamination of the coatings and initiation of the corrosion. Since, bone contains nanometer-size carbonated hydroxyapatite crystal (dahllite), it is more logical to use "carbonated hydroxyapatite" as a coating material for the orthopedic and dental implants. Most of the research efforts were devoted towards nanoparticles of hydroxyapatite-coated implants. The nanoparticle of carbonated hydroxyapatite-coated implants is not investigated comprehensively. This Phase I research is based on the synthesis of unagglomerated nanoparticles of the carbonated hydroxyapatite as well as coating of Ti-alloy with nanoparticles of carbonated hydroxyapatite at the room temperature. The proposed feasibility study will increase the bond strength of coating, reduce corrosion and subsequently increase the lifespan of the prosthesis. The commercial impact of the above research will be very significant to the US economy. It will minimize the pain and suffering of the patients. The federal government and the insurance industries will benefit in Billion of dollars from the reduced rate of revision of the prosthesis, reduction in the consumption of analgesics and the lost wages. The potential market size of the orthopedic implants is $8 Billion/year by 2007.

描述(申请人提供)：在过去的五年中，髋关节置换率增加到21%。需要修改的髋关节或膝关节置换手术的比例保持在16%到17%之间。骨水泥全髋关节置换术通常是首选，但骨水泥植入物的寿命只有10-12年。骨水泥碎片引起的骨溶解和种植体内的腐蚀是导致假体失效的主要原因。许多研究表明，羟基磷灰石涂层植入物具有更好的生物相容性和有效性。使用劣质原料和等离子喷涂涂层过程中的高温是羟基磷灰石涂层植入物中杂质的主要来源。这会导致涂层结合强度降低，涂层剥落，引发腐蚀。由于骨中含有纳米尺寸的碳酸化羟基磷灰石晶体(达利石)，因此将其作为骨科和牙科植入物的涂层材料更为合理。大部分研究工作都致力于羟基磷灰石涂层植入物的纳米颗粒。碳酸化羟基磷灰石涂层植入物的纳米颗粒还没有得到全面的研究。 这一阶段的研究是基于合成未团聚的碳酸化羟基磷灰石纳米颗粒以及在室温下在钛合金表面包覆碳酸化羟基磷灰石纳米颗粒。拟议的可行性研究将增加涂层的结合强度，减少腐蚀，从而延长假体的寿命。上述研究的商业影响将对美国经济产生非常重大的影响。这将最大限度地减轻患者的痛苦和痛苦。联邦政府和保险业将从假肢修复率的降低、止痛药消耗量的减少和工资的损失中受益数十亿美元。到2007年，骨科植入物的潜在市场规模为80亿美元/年。