Nano-Apatite Coating of the Porous Surface of Implants

植入物多孔表面的纳米磷灰石涂层

• 批准号: 7062414
• 负责人: CHITTARANJAN P SINGH
• 金额: $ 19.92万
• 依托单位: NANO INTERFACE TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2007-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062414
• 关键词: X ray crystallography; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biotechnology; carbonates; corrosions; cost effectiveness; dental prosthesis; hip prosthesis; hydroxyapatites; infrared spectrometry; joint prosthesis; knee; mechanical stress; medical implant science; nanotechnology; orthopedics; surface coating; surface property; titanium

DESCRIPTION (provided by applicant): The rate of hip replacement has increased to 21% in the last five years. The proportion of hip or knee replacement procedures that needed revision remained in between 16% and 17%. The cemented total hip replacement is normally preferred but cemented implants have only 10-12 years of life span. The osteolysis caused by the fragments of the cement and corrosion in the implants are main reason of the failure of the prosthesis. A number of studies have revealed better biocompatibility and effectiveness of hydroxyapatite-coated implants. The use of poor quality of starting material and the high temperature attained during the plasma-sprayed coatings are the major source of impurities in the hydroxyapatite-coated implants. This leads to weaker bond strength of the coatings, delamination of the coatings and initiation of the corrosion. Since, bone contains nanometer-size carbonated hydroxyapatite crystal (dahllite), it is more logical to use "carbonated hydroxyapatite" as a coating material for the orthopedic and dental implants. Most of the research efforts were devoted towards nanoparticles of hydroxyapatite-coated implants. The nanoparticle of carbonated hydroxyapatite-coated implants is not investigated comprehensively. This Phase I research is based on the synthesis of unagglomerated nanoparticles of the carbonated hydroxyapatite as well as coating of Ti-alloy with nanoparticles of carbonated hydroxyapatite at the room temperature. The proposed feasibility study will increase the bond strength of coating, reduce corrosion and subsequently increase the lifespan of the prosthesis. The commercial impact of the above research will be very significant to the US economy. It will minimize the pain and suffering of the patients. The federal government and the insurance industries will benefit in Billion of dollars from the reduced rate of revision of the prosthesis, reduction in the consumption of analgesics and the lost wages. The potential market size of the orthopedic implants is $8 Billion/year by 2007.

描述（由申请人提供）：髋关节置换术的比例在过去五年中增加到21%。髋关节或膝关节置换术需要翻修的比例保持在16%至17%之间。骨水泥全髋关节置换术通常是首选，但骨水泥假体只有10-12年的寿命。骨水泥碎裂和种植体腐蚀引起的骨溶解是导致假体失效的主要原因。许多研究表明羟基磷灰石包覆种植体具有更好的生物相容性和有效性。等离子喷涂涂层过程中使用的劣质起始材料和达到的高温是羟基磷灰石涂层植入物中杂质的主要来源。这导致涂层的结合强度变弱，涂层分层并引发腐蚀。由于骨中含有纳米大小的碳化羟基磷灰石晶体（大石石），因此使用“碳化羟基磷灰石”作为骨科和牙科植入物的涂层材料更合乎逻辑。大部分的研究工作都集中在羟基磷灰石包覆的纳米颗粒植入物上。纳米碳化羟基磷灰石包覆种植体的研究尚不全面。