A Novel Needle-based X-ray System

一种新型针基 X 射线系统

• 批准号: 6880318
• 负责人: George Gutman
• 金额: $ 10万
• 依托单位: ADVANCED X-RAY TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6880318
• 关键词: X ray; bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; neoplasm /cancer radiation therapy; neurosurgery; optics; phantom model; radiation therapy dosage; radionuclide implant; statistics /biometry

DESCRIPTION (provided by applicant): The main objective of this project is to design, fabricate and experimentally research the application of capillary x-ray optics as a means of elevating the dose rate of the radiation produced by a needle-based x-ray system. The goal is to reach the dose rate of 10 Gy/hour at a distance 5 mm from the pseudo-target. The other objective is to apply capillary x-ray optics to creating a high intensity x-ray source that can produce a narrow (diameter lesser than 1.0 ram) quasi-parallel x-ray beam for possible usage in neurosurgery. The offered x-ray system is based on an insertable needle x-ray source with which the x-ray beam properties such as (energy), intensity (delivery time), and beam orientation (exposure region) could be controlled. To achieve the aims of the project I, we will: (1) design, build and test a capillary x-ray lens, (2) incorporate the capillary lens into an optical collimator, (3) integrate the collimator into a prototype needle-based x-ray system; (3) perform calculations of x-ray dose distribution from the pseudo-target using Monte-Carlo simulation; (4) carry out experiments to characterize dose and dose rate distribution of the radiation produced by the pseudo-target, and (5) measure scattering of a sharply focused x-ray beam in tissue imitating materials. Phase II of the project will be devoted to building an extended energy range (8keV-60 keV), high dose rate x-ray system incorporating new x-ray focusing/collimating optics. A treatment planning system for the needle x-ray device will be developed.

描述（由申请人提供）： 本计画的主要目的是设计、制作及实验研究毛细管式X光光学元件，以提升针式X光系统所产生的辐射剂量率。目标是在距离伪靶5 mm处达到10戈伊/小时的剂量率。另一个目标是应用毛细管X射线光学器件来创建高强度X射线源，该高强度X射线源可以产生窄（直径小于1.0mm）准平行X射线束，用于神经外科手术中的可能使用。所提供的X射线系统基于可插入的针式X射线源，通过该X射线源可以控制X射线束特性，例如（能量）、强度（输送时间）和射束方向（暴露区域）。为了实现项目I的目标，我们将：（1）设计、制造和测试毛细管X射线透镜，（2）将毛细管透镜与光学准直器结合，（3）将准直器与基于针的X射线系统原型结合，（3）使用蒙特-卡罗模拟计算来自伪靶的X射线剂量分布，（4）将毛细管透镜与光学准直器结合，（5）将准直器与基于针的X射线系统原型结合。（4）进行实验以表征由伪目标产生的辐射的剂量和剂量率分布，以及（5）测量尖锐聚焦的X射线束在组织模拟材料中的散射。 该项目的第二阶段将致力于建立一个扩展的能量范围（8 keV-60 keV），高剂量率X射线系统，包括新的X射线聚焦/准直光学。将开发针式X射线设备的治疗计划系统。