A Novel Needle-Based X-Ray System

一种新型针基 X 射线系统

• 批准号: 7216118
• 负责人: George Gutman
• 金额: $ 37万
• 依托单位: ADVANCED X-RAY TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7216118
• 关键词: X ray

DESCRIPTION (provided by applicant): The long-term objective of the project is to develop, clinically test and commercialize the novel insertable x-ray device developed by AXT. This portable x-ray needle, is intended for delivery of low energy, high RBE radiation directly to the tumour beds and is considered to be a viable alternative to radioactive sources used in the High Dose Rate Brachytherapy. The main advantages of AXT's x-ray device include such features as a controllable on/off mode, exceptional stability of the produced radiation, adjustable dose rate, and the ability to function in a conventional operating room with almost no radiological exposure to staff. The initial application of the device is the accelerated partial breast irradiation. The main goal of the Phase II project is to design, build and test a new model of the x-ray needle with an elevated dose rate of the produced radiation (1Gy/min at 10mm in tissue). Other goals include the development of low-energy (8-18 keV) dosimetry protocols and a treatment planning approach involving the x-ray needle. To achieve the stated goals the following specific aims of the project have to be fulfilled. The specific aims of the project are: (i) design, build and test an ellipsoidal and Johansson type concentrators fabricated from a Highly Oriented Pyrolytic Graphite, (2) incorporate the concentrators into an optical collimator, (3) integrate the collimators into an x-ray needle, (4) perform measurements of dose rate and dose rate spatial distribution (isodose), (5) design and build a balloon applicator and test it jointed with an x-ray needle, (6) install an x-ray needle device in a conventional movable arm. The potential market for such device is significant. It is estimated that more than 275,000 women in the United States are annually diagnosed with breast cancer and about 50% of them are treated with radiotherapy. Development of the new model of AXT's insertable x-ray device offers hope and promise for cure and improvement to the quality of life for many affected people.

描述（由申请人提供）：该项目的长期目标是开发、临床测试和商业化 AXT 开发的新型可插入 X 射线设备。这种便携式 X 射线针旨在将低能量、高 RBE 辐射直接传送到肿瘤床，被认为是高剂量率近距离放射治疗中使用的放射源的可行替代品。 AXT 的 X 射线设备的主要优点包括可控开/关模式、所产生辐射的卓越稳定性、可调节剂量率以及能够在传统手术室中运行而工作人员几乎不会受到辐射照射等功能。该装置的最初应用是加速局部乳房照射。第二阶段项目的主要目标是设计、建造和测试一种新模型的 X 射线针，其产生的辐射剂量率较高（组织中 10 毫米处为 1Gy/min）。其他目标包括开发低能量 (8-18 keV) 剂量测定方案和涉及 X 射线针的治疗计划方法。为了实现既定目标，必须实现该项目的以下具体目标。该项目的具体目标是：(i) 设计、建造和测试由高取向热解石墨制成的椭球体和约翰逊型聚光器，(2) 将聚光器集成到光学准直器中，(3) 将准直器集成到 X 射线针中，(4) 测量剂量率和剂量率空间分布（等剂量），(5) 设计和构建气球施放器并进行测试 与X射线针连接，(6)将X射线针装置安装在传统的活动臂上。这种设备的潜在市场是巨大的。据估计，美国每年有超过 275,000 名女性被诊断患有乳腺癌，其中约 50% 接受放射治疗。 AXT 新型插入式 X 射线设备的开发为许多受影响人群的治愈和改善生活质量带来了希望和希望。