A Novel Needle-Based X-Ray System

一种新型针基 X 射线系统

• 批准号: 7294924
• 负责人: George Gutman
• 金额: $ 38万
• 依托单位: ADVANCED X-RAY TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7294924
• 关键词: Affect; Anodes; Beds; Brachytherapy; Breast; Cancerous; Cathodes; Collimator; Depth; Development; Devices; Diagnosis; Dose-Rate; Electron Beam; Electrons; Employee Strikes; Exposure to; Failure; Fluorescence; Generations; Goals; Grant; Heating; High-Dose Rate Brachytherapy; Joints; Legal patent; Marketing; Measurement; Metals; Modeling; Natural graphite; Needles; Operating Rooms; Operative Surgical Procedures; Optics; Output; Penetration; Phase; Physiologic pulse; Postoperative Period; Procedures; Production; Protocols documentation; Pulse taking; Quality of life; Radiation; Radiation therapy; Radioactive; Radioisotopes; Radiosurgery; Range; Relative Biological Effectiveness; Roentgen Rays; Science; Shapes; Source; Spatial Distribution; Staging; System; Techniques; Technology; Testing; Tissues; Titan; Tube; United States; United States National Institutes of Health; Upper arm; Vacuum; Water; Woman; absorption; attenuation; base; breast lumpectomy; cell killing; concept; design; dosimetry; evaporation; irradiation; magnetic field; malignant breast neoplasm; novel; quantum; treatment planning; tumor

DESCRIPTION (provided by applicant): The long-term objective of the project is to develop, clinically test and commercialize the novel insertable x-ray device developed by AXT. This portable x-ray needle, is intended for delivery of low energy, high RBE radiation directly to the tumour beds and is considered to be a viable alternative to radioactive sources used in the High Dose Rate Brachytherapy. The main advantages of AXT's x-ray device include such features as a controllable on/off mode, exceptional stability of the produced radiation, adjustable dose rate, and the ability to function in a conventional operating room with almost no radiological exposure to staff. The initial application of the device is the accelerated partial breast irradiation. The main goal of the Phase II project is to design, build and test a new model of the x-ray needle with an elevated dose rate of the produced radiation (1Gy/min at 10mm in tissue). Other goals include the development of low-energy (8-18 keV) dosimetry protocols and a treatment planning approach involving the x-ray needle. To achieve the stated goals the following specific aims of the project have to be fulfilled. The specific aims of the project are: (i) design, build and test an ellipsoidal and Johansson type concentrators fabricated from a Highly Oriented Pyrolytic Graphite, (2) incorporate the concentrators into an optical collimator, (3) integrate the collimators into an x-ray needle, (4) perform measurements of dose rate and dose rate spatial distribution (isodose), (5) design and build a balloon applicator and test it jointed with an x-ray needle, (6) install an x-ray needle device in a conventional movable arm. The potential market for such device is significant. It is estimated that more than 275,000 women in the United States are annually diagnosed with breast cancer and about 50% of them are treated with radiotherapy. Development of the new model of AXT's insertable x-ray device offers hope and promise for cure and improvement to the quality of life for many affected people.

描述（由申请人提供）：该项目的长期目标是开发，临床测试和商业化AXT开发的新型可插入X射线设备。这款便携式X射线针旨在直接向肿瘤床传递低能量，高RBE辐射，被认为是高剂量率近距离近距离近距离近距离近距离的放射性源的可行替代品。 AXT的X射线设备的主要优点包括可控的开/关模式，产生的辐射的出色稳定性，可调节剂量的稳定性以及在传统手术室中运作的能力，几乎没有放射性的员工。该设备的最初应用是加速的部分乳房照射。 II期项目的主要目标是设计，构建和测试X射线针的新模型，其剂量速度升高的辐射速率（在组织中为10mm）。其他目标包括开发低能量（8-18 KEV）剂量学方案以及涉及X射线针的治疗计划方法。为了实现既定目标，必须实现该项目的以下具体目标。该项目的具体目的是：（i）设计，构建和测试椭圆形和约翰逊型浓缩剂，该椭圆形和约翰逊型浓缩剂是由高度定向的热解石墨制成的，（2）将浓缩剂纳入光学单相仪中，（3）将准胶器整合到X射线针中的X射线和剂量速率和剂量速率分布（4）的（4）ISSPAT型（4）IS（4）IS（ISOD）（ISOD），（5）用X射线针接合，（6）在传统的可移动臂中安装X射线针头设备。这种设备的潜在市场很重要。据估计，在美国，每年有275,000多名妇女被诊断出患有乳腺癌，其中约50％接受了放疗。 AXT可插入的X射线设备的新模型的开发为许多受影响的人提供了希望和有望改善生活质量的希望和希望。