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Viral evasion of innate immunity: have we misunderstood one of the world's most widespread viruses?

病毒逃避先天免疫：我们是否误解了世界上最普遍的病毒之一？

基本信息

批准号：
2734797
负责人：
金额：
--
依托单位：
St George's, University of London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2734797
关键词：
Viral evasion innate immunity misunderstood

项目摘要

TBCThe innate immune response is the first line of defence in viral infection, where production of cellular anti-viral proteins by interferon attempt to control infection. Human cytomegalovirus (HCMV) is a widespread global pathogen affecting some of societies most vulnerable people. Evasion of innate immunity by HCMV laboratory strains has previously been studied. However, evasion of innate immunity by HCMV strains that resemble wild type HCMV has not yet been fully explored. We have identified viruses that can (wild type strain) and cannot (lab strain) evade the innate immune response. By comparing infection of these viruses we will examine how HCMV influences interferon production and the function of anti-viral proteins regulated by interferon. We will then identify what viral genes are responsible for influencing the aforementioned processes. This project will help us understand how we may have misunderstood interaction of a global pathogen with the innate immune system. This project has important academic impact elsewhere as it may help identify viral proteins in viruses related to HCMV that are important for control of innate immunity. As interferon production may be important for HCMV vaccine design, this work may also have important translational impacts.

先天免疫反应是病毒感染的第一道防线，通过干扰素产生细胞抗病毒蛋白试图控制感染。人类巨细胞病毒（HCMV）是一种广泛存在的全球性病原体，影响着社会中一些最脆弱的人群。HCMV实验室毒株逃避先天免疫的研究以前已经进行过。然而，与野生型HCMV相似的HCMV毒株逃避先天免疫的机制尚未得到充分研究。我们已经确定了能够（野生型株）和不能（实验室株）逃避先天免疫反应的病毒。通过比较这些病毒的感染，我们将研究HCMV如何影响干扰素的产生和干扰素调节的抗病毒蛋白的功能。然后，我们将确定哪些病毒基因负责影响上述过程。这个项目将帮助我们理解我们是如何误解了全球性病原体与先天免疫系统的相互作用。该项目在其他地方具有重要的学术影响，因为它可能有助于识别与HCMV相关的病毒中的病毒蛋白，这些病毒蛋白对控制先天免疫很重要。由于干扰素的产生可能对HCMV疫苗的设计很重要，这项工作也可能具有重要的转化影响。