Flaviviruses must come of age: design of stable, mature particles by structural vaccinology

我们已经建立了一个强大的工具集，结合先进的结构生物学和快速病毒工程，使我们能够以新的方式研究黄病毒的组装。该项目将整合这些方法来研究我们在医学相关黄病毒（包括登革热病毒）结构中发现的新配体的作用，并描绘黄病毒的新成熟途径，这将用于设计更安全，更有效的黄病毒疫苗。

We have established a powerful toolset combining advanced structural biology and rapid virus engineering that allows us investigate the assembly of flaviviruses in novel ways. This project will integrate these approaches to investigate the role of new ligands that we have identified in the structure of medically-relevant flaviviruses including dengue virus and delineate a novel maturation path for flaviviruses, which will be used to design safer and more effective flavivirus vaccines.