Flightless I, a terget for new wound therapies

Flightless I，新伤口疗法的目标

• 批准号: nhmrc : 508004
• 负责人: Prof Allison Cowin
• 金额: $ 22.66万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/flightless-i-terget-wound-therapies/115516
• 关键词: Flightless; terget; new; wound; therapies

Wounds, burns and scalds are frequent injuries which can lead to deformity, disfigurement and loss of movement. We have shown that the cytoskeletal protein, Flightless I (FliI), is an important regulator of wound repair. We plan to further investigate FliI in wound and burn injuries using new cell-specific transgenic animal models and to develop a new FliI-antibody based therapy to treat wound and burn injuries.

伤口、烧伤和烫伤是常见的伤害，可导致畸形、毁容和丧失运动能力。我们已经证明，细胞骨架蛋白Flightless I （FliI）是伤口修复的重要调节因子。我们计划利用新的细胞特异性转基因动物模型进一步研究FliI在创面和烧伤损伤中的作用，并开发一种新的基于FliI抗体的创面和烧伤治疗方法。