Flightless I, A target for new wound therapies

Flightless I，新伤口治疗的目标

• 批准号: nhmrc : 1002009
• 负责人: Prof Allison Cowin
• 金额: $ 42.11万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/flightless-i-target-wound-therapies/108762
• 关键词: Flightless; target; new; wound; therapies

Wounds and burn injuries are frequent injuries which can lead to deformity, disfigurement and loss of movement. The cytoskeleton is integral to the wound healing process and we have shown that a specific cytoskeletal protein, Flightless I (Flii), is an important regulator of wound repair. During the course of this fellowship I plan to further my investigations into the function and regulation of Flii in wounds and aim to develop new therapies for treating wounds and reducing scar formation.

伤口和烧伤是常见的伤害，可导致畸形，毁容和丧失运动能力。细胞骨架是伤口愈合过程中不可或缺的一部分，我们已经证明了一种特定的细胞骨架蛋白，Flightless I (Flii)，是伤口修复的重要调节因子。在此期间，我计划进一步研究Flii在伤口中的功能和调节，并致力于开发治疗伤口和减少疤痕形成的新疗法。