Modulating sphingolipid signalling to enhance wound healing

调节鞘脂信号传导以促进伤口愈合

• 批准号: nhmrc : 1124961
• 负责人: Prof Allison Cowin
• 金额: $ 47.66万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-sphingolipid-signalling-wound-healing/947473
• 关键词: Modulating; sphingolipid; signalling; enhance; wound

Impaired wound healing is a major problem for diabetics, who often suffer with chronic unresolved wounds with serious effects on their quality of life and mortality. We have recently discovered a new pathway involving sphingolipids that shows great promise to improve wound healing in diabetics. In this project we will examine the targeting of this pathway, using existing and newly developed agents, to improve wound healing in advanced pre-clinical models of diabetes.

伤口愈合不良是糖尿病患者的主要问题，糖尿病患者经常遭受慢性未解决的伤口，严重影响他们的生活质量和死亡率。我们最近发现了一种涉及鞘脂的新途径，该途径在改善糖尿病患者伤口愈合方面具有很大的前景。在这个项目中，我们将研究这一途径的靶向，使用现有的和新开发的药物，以改善糖尿病的高级临床前模型中的伤口愈合。