Modulating sphingolipid signalling to enhance wound healing

创面愈合受损是糖尿病患者的主要问题，他们经常遭受长期未解决的创面的困扰，严重影响他们的生活质量和死亡率。我们最近发现了一种涉及鞘磷脂的新途径，它显示出改善糖尿病患者伤口愈合的巨大希望。在这个项目中，我们将使用现有的和新开发的药物来研究这一途径的靶向性，以改善糖尿病高级临床前模型的伤口愈合。

Impaired wound healing is a major problem for diabetics, who often suffer with chronic unresolved wounds with serious effects on their quality of life and mortality. We have recently discovered a new pathway involving sphingolipids that shows great promise to improve wound healing in diabetics. In this project we will examine the targeting of this pathway, using existing and newly developed agents, to improve wound healing in advanced pre-clinical models of diabetes.