Environmental maternal effects and intergenerational inheritance

项目亮点：-生物快速应对突发环境变化的机制-母亲感知环境应激信号以产生抗应激后代-使用最新的基因组编辑工具，以及生物化学和下一代测序概述突然的环境变化对许多生物的生存具有挑战性。一些生物体进化出了应对不确定性的机制，通过感知环境并将选择的适应性特征传递给下一代。我们以freiburgensis线虫为模型，研究了母体感知到的环境信号对种系进行修饰以产生抗逆性后代的机制。在这种线虫中，同一种类的线虫产生的化学物质被用作过度拥挤的信号。因此，通过感知这些化学物质，母亲“准备”后代抵御过度拥挤条件下出现的食物缺乏。其后代以幼虫的形式阻止发育，并能在没有食物的情况下存活数月。一旦在一个良好的环境中，幼虫恢复发育成为自我受精的成虫。该项目的主要目标是确定母亲感知的化学性质，感觉神经元如何将信息传递给性腺，以及生殖细胞的变化如何导致不同种类的后代。

Project Highlights: -Mechanisms by which organisms rapidly respond to sudden environmental changes-Mother senses environmental stress signals to produce stress-resistant progeny-Use of the most recent genome-editing tools, as well as biochemistry, and next-gen sequencingOverview Sudden environmental changes are challenging for the survival of many organisms. Some organisms evolved mechanisms to cope with uncertainty, by sensing the environment and transmitting selected adaptive traits to the next generation.We use the nematode Auanema freiburgensis as model to study the mechanisms by which environmental signals sensed by the mother results in the modification of the germline to produce stress-resistant progeny. In this nematode, chemicals produced by nematodes of the same species are used as signals for overcrowding. Thus, by sensing these chemicals, the mother 'prepares' the progeny to withstand the lack of food that occurs in overcrowded conditions. The progeny arrests development in the form of larvae, and can survive in the absence of food for several months. Once in a benign environment, the larvae resume development to become self-fertilizing adults. The main objectives of the project are to identify the chemical nature sensed by the mothers, how the sensory neurons convey the information to the gonad, and how the germline changes result in different kinds of progeny.