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Environmental maternal effects and intergenerational inheritance

环境母性影响和代际遗传

基本信息

批准号：
2740366
负责人：
金额：
--
依托单位：
University of Warwick
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2740366
关键词：
Environmental maternal effects intergenerational inheritance

项目摘要

Project Highlights: -Mechanisms by which organisms rapidly respond to sudden environmental changes-Mother senses environmental stress signals to produce stress-resistant progeny-Use of the most recent genome-editing tools, as well as biochemistry, and next-gen sequencingOverview Sudden environmental changes are challenging for the survival of many organisms. Some organisms evolved mechanisms to cope with uncertainty, by sensing the environment and transmitting selected adaptive traits to the next generation.We use the nematode Auanema freiburgensis as model to study the mechanisms by which environmental signals sensed by the mother results in the modification of the germline to produce stress-resistant progeny. In this nematode, chemicals produced by nematodes of the same species are used as signals for overcrowding. Thus, by sensing these chemicals, the mother 'prepares' the progeny to withstand the lack of food that occurs in overcrowded conditions. The progeny arrests development in the form of larvae, and can survive in the absence of food for several months. Once in a benign environment, the larvae resume development to become self-fertilizing adults. The main objectives of the project are to identify the chemical nature sensed by the mothers, how the sensory neurons convey the information to the gonad, and how the germline changes result in different kinds of progeny.

项目亮点：- 生物体对突发环境变化的快速反应机制-母亲感知环境压力信号以产生抗压力后代-使用最新的基因组编辑工具，以及生物化学和下一代测序概述突发环境变化对许多生物体的生存具有挑战性。一些生物进化的机制，以科普不确定性，通过感知环境和传输选定的适应性traffics.We为模型的Auanema freiburgensis线虫研究的机制，通过环境信号的母亲在生殖细胞的修改，产生抗应激后代的结果。在这种线虫中，同种线虫产生的化学物质被用作过度拥挤的信号。因此，通过感知这些化学物质，母亲“准备”后代承受在过度拥挤的条件下发生的食物缺乏。后代以幼虫的形式停止发育，并且可以在没有食物的情况下存活数月。一旦在一个良性的环境中，幼虫恢复发展成为自我繁殖的成年人。该项目的主要目标是确定母亲感觉到的化学性质，感觉神经元如何将信息传递到性腺，以及种系变化如何导致不同种类的后代。