Environmental bisphenol exposure, infant brain and behavior: Human and animal models

该提案利用了纵向出生队列研究的基础设施（ 哥伦比亚儿童环境健康中心），并补充了我们对 产前双酚暴露对婴儿神经系统功能、注意力和母亲行为的影响 （R01ES030950）。先前的动物研究显示BP暴露对后代大脑的不利影响 R 01旨在将这些发现扩展到人类。这 行政补充调查暴露于歧视和COVID的经验的影响- 19-围产期抑郁症（PeriPD）和睡眠健康的相关压力在这些相同的妇女。PeriPD和 睡眠障碍在围产期很常见，对母婴互动和儿童发育有负面影响。 健康成果。尽管如此，PeriPD和睡眠健康状况不佳的病因尚不清楚。经验 歧视和COVID-19相关的压力，这些压力对种族/少数民族造成了不成比例的负担 和经济上处于不利地位的背景，已被证明会增加精神不佳的风险， 睡眠健康尽管如此，它们在围产期的独立和协同作用尚未得到证实。 彻底调查。了解产妇围产期心理健康和睡眠的上游风险因素 健康可为制定预防和干预战略提供可采取行动的信息。投资R 01 从产科诊所招募低收入、少数民族/种族背景的孕妇， 在哥伦比亚长老会医院工作在这个代表性不足的人群中，PeriPD和睡眠不良的风险 健康是高。这项提案将资助评估围PD（自我报告症状，产前精神病， 访谈）、PeriPD的神经相关性（fMRI）以及睡眠健康的主观和客观测量（自我评估）。 睡眠质量报告、1周活动记录仪和2天睡眠EEG监测）。我们会调查 歧视经历和COVID-19相关压力与测量结果之间的关联 在一个来自低收入背景的拉丁裔妇女样本中， 和COVID-19相关的压力。我们假设，增加的歧视和COVID-19- 相关的压力将与产后期间抑郁症的增加和睡眠健康状况较差有关。 我们的计划与特别关注通知NOT-OD-21-071的目标一致，目标是“社会心理和 与影响孕产妇心理健康的COVID-19大流行相关的行为健康风险因素， 结构性种族主义和歧视对孕产妇保健成果的影响 在COVID-19的背景下”。这一建议填补了在理解歧视的影响方面的一个关键空白， 来自低收入、少数民族/种族背景的母亲对PeriPD和睡眠的COVID-19相关压力 面临歧视和COVID-19相关压力的高风险。

This proposal leverages the infrastructure of longitudinal birth cohort study (the Fair Start Cohort within the Columbia Center for Children's Environmental Health) and supplements our investigation of the effects of prenatal bisphenol (BP) exposure on infant nervous system functioning and attention and maternal caregiving (R01ES030950) within the cohort. Prior animal studies show adverse effects of BP exposure on offspring brain development and mother-infant interaction; the R01 seeks to extend these findings to humans. This Administrative Supplement investigates the effects of exposure to experiences of discrimination and COVID- 19-related stress on peripartum depression (PeriPD) and sleep health in these same women. PeriPD and sleep disturbances are common in the perinatal period and negatively affect mother-infant interaction and child health outcomes. Nonetheless etiology of PeriPD and poor sleep health are unclear. Experiences of discrimination and COVID-19-related stress, which burden disproportionately people from racial/ethnic minority and economically disadvantaged backgrounds, have been shown to increase the risk for poor mental and sleep health. Nonetheless, their independent and synergistic role in the perinatal period has not been thoroughly investigated. Understanding upstream risk factors for maternal perinatal mental health and sleep health may provide actionable information to develop prevention and intervention strategies. The funded R01 recruits pregnant women from low income, ethnic/racial minority backgrounds from obstetric clinics associated with Columbia Presbyterian Hospital. In this underrepresented population, the risk for PeriPD and poor sleep health is high. This proposal will fund the assessment of PeriPD (self-report of symptoms, prenatal psychiatric interview), neural correlates of PeriPD (fMRI), and subjective and objective measures of sleep health (self- report of sleep quality, 1-week actigraphy, and 2 days sleep EEG monitoring). We will then investigate associations between experiences of discrimination and COVID-19-related stress and the measured outcomes in a sample of Latinx women from low income backgrounds who are at high risk of exposure to discrimination and COVID-19-related stress. We hypothesize that increased exposure to discrimination and COVID-19- related stress will be associated with increased depression and poorer sleep health in the postpartum period. Our plan is consistent with goals of the Notice of Special interest NOT-OD-21-071 targeting “psychosocial and behavioral health risk factors related to the COVID-19 pandemic that affect maternal mental health and functioning outcome and the impact of structural racism and discrimination (SRD) on maternal health outcomes in the context of COVID-19”. This proposal fills a critical gap in understanding the impact of discrimination and COVID-19-related stress on PeriPD and sleep in mothers from low income, ethnic/racial minority backgrounds at high risk of experiencing both discrimination and COVID-19-related stress.