Environmental bisphenol exposure, infant brain and behavior: Human and animal models

环境双酚暴露、婴儿大脑和行为：人类和动物模型

• 批准号: 10393372
• 负责人: AMY MARGOLIS
• 金额: $ 63.96万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393372
• 关键词: Address; Administrative Supplement; Adverse effects; Affect; Animal Model; Animals; Architecture; Attention; Birth; Brain; COVID-19; COVID-19 pandemic; Child; Child Health; Clinic; Clinical; Cohort Studies; DSM-V; Data; Data Collection; Development; Diagnosis; Dimensions; Discipline of obstetrics; Discrimination; Drowsiness; Economically Deprived Population; Electroencephalography; Environmental Health; Etiology; Exposure to; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Home; Hospitals; Human; Individual; Infant; Infant Health; Infrastructure; Interview; Investigation; Joints; Latinx; Link; Literature; Low income; Maternal Health; Measures; Mental Depression; Mental Health; Monitor; Mothers; Neighborhoods; Nervous System Physiology; Neurophysiology - biologic function; New York City; Outcome; Outcome Measure; Parents; Patient Self-Report; Perinatal; Pittsburgh Sleep Quality Index; Polysomnography; Population; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Presbyterian Church; Prevention program; Questionnaires; Race; Reporting; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Stages; Sleep disturbances; Stress; Structural Racism; Structure; Surveys; Symptoms; Testing; Underrepresented Populations; Woman; actigraphy; behavioral health; brain behavior; center for epidemiological studies depression scale; clinically significant; cohort; depressive symptoms; disadvantaged background; ethnic disparity; ethnic minority population; experience; financial incentive; high risk; human model; individualized prevention; interest; intervention program; maternal caregiving; maternal outcome; mental function; negative affect; neural correlate; offspring; pandemic disease; perinatal mental health; perinatal period; peripartum depression; poor sleep; prenatal; preventive intervention; psychosocial; racial and ethnic; racial discrimination; racial minority; recruit; reward circuitry; satisfaction; sleep health; sleep quality

This proposal leverages the infrastructure of longitudinal birth cohort study (the Fair Start Cohort within the Columbia Center for Children's Environmental Health) and supplements our investigation of the effects of prenatal bisphenol (BP) exposure on infant nervous system functioning and attention and maternal caregiving (R01ES030950) within the cohort. Prior animal studies show adverse effects of BP exposure on offspring brain development and mother-infant interaction; the R01 seeks to extend these findings to humans. This Administrative Supplement investigates the effects of exposure to experiences of discrimination and COVID- 19-related stress on peripartum depression (PeriPD) and sleep health in these same women. PeriPD and sleep disturbances are common in the perinatal period and negatively affect mother-infant interaction and child health outcomes. Nonetheless etiology of PeriPD and poor sleep health are unclear. Experiences of discrimination and COVID-19-related stress, which burden disproportionately people from racial/ethnic minority and economically disadvantaged backgrounds, have been shown to increase the risk for poor mental and sleep health. Nonetheless, their independent and synergistic role in the perinatal period has not been thoroughly investigated. Understanding upstream risk factors for maternal perinatal mental health and sleep health may provide actionable information to develop prevention and intervention strategies. The funded R01 recruits pregnant women from low income, ethnic/racial minority backgrounds from obstetric clinics associated with Columbia Presbyterian Hospital. In this underrepresented population, the risk for PeriPD and poor sleep health is high. This proposal will fund the assessment of PeriPD (self-report of symptoms, prenatal psychiatric interview), neural correlates of PeriPD (fMRI), and subjective and objective measures of sleep health (self- report of sleep quality, 1-week actigraphy, and 2 days sleep EEG monitoring). We will then investigate associations between experiences of discrimination and COVID-19-related stress and the measured outcomes in a sample of Latinx women from low income backgrounds who are at high risk of exposure to discrimination and COVID-19-related stress. We hypothesize that increased exposure to discrimination and COVID-19- related stress will be associated with increased depression and poorer sleep health in the postpartum period. Our plan is consistent with goals of the Notice of Special interest NOT-OD-21-071 targeting “psychosocial and behavioral health risk factors related to the COVID-19 pandemic that affect maternal mental health and functioning outcome and the impact of structural racism and discrimination (SRD) on maternal health outcomes in the context of COVID-19”. This proposal fills a critical gap in understanding the impact of discrimination and COVID-19-related stress on PeriPD and sleep in mothers from low income, ethnic/racial minority backgrounds at high risk of experiencing both discrimination and COVID-19-related stress.

这一建议充分利用了纵向出生队列研究的基础设施(公平开始队列 哥伦比亚儿童环境健康中心)，并补充了我们对 产前接触双酚对婴儿神经系统功能、注意力和母亲照料的影响 (R01ES030950)在队列中。先前的动物研究表明，接触BP对子代大脑有不利影响 发育和母婴互动；R01试图将这些发现推广到人类。这 《行政补编》调查了遭受歧视和COVID的影响-- 19-与围产期抑郁(PeriPD)和睡眠健康相关的压力在这些女性中。PeriPD和 睡眠障碍在围产期很常见，对母婴互动和孩子产生负面影响 健康结果。然而，周围性帕金森病和睡眠健康状况不佳的病因尚不清楚。经验和经验 歧视和与新冠肺炎相关的压力，给来自种族/少数民族的人带来了不成比例的负担 和经济上处于不利地位的背景，已被证明增加了精神和心理障碍的风险 睡眠健康。尽管如此，它们在围产期的独立和协同作用尚未得到 彻底调查过了。了解母亲围产期心理健康和睡眠的上游危险因素 卫生部门可提供可采取行动的信息，以制定预防和干预策略。受资助的R01 从相关产科诊所招募低收入、少数族裔背景的孕妇 哥伦比亚长老会医院。在这一代表性不足的人群中，患周期性帕金森病和睡眠不佳的风险 健康状况很好。这项提议将资助对围产期精神障碍的评估(症状自我报告，产前精神疾病 访谈)，PeriPD的神经相关性(FMRI)，以及睡眠健康的主观和客观测量(自评 睡眠质量报告、1周动态描记和2天睡眠脑电监测)。然后我们将进行调查 歧视经历、新冠肺炎相关应激与测量结果的关系 在低收入背景的拉丁裔女性样本中，她们面临着高风险的歧视 和新冠肺炎相关的压力。我们假设，暴露在歧视和新冠肺炎面前的增加- 相关的压力将与产后抑郁加剧和睡眠健康状况变差有关。 我们的计划与特别关注通知NOT-OD-21-071的目标是一致的，目标是“社会心理和 影响孕产妇心理健康和新冠肺炎大流行的行为健康危险因素 功能结果和结构性种族主义和歧视(SRD)对孕产妇健康结果的影响 在新冠肺炎的背景下“。这项建议填补了在理解歧视和 低收入、少数民族母亲新冠肺炎相关应激对围产期抑郁和睡眠的影响 同时面临歧视和新冠肺炎相关压力的风险很高。