Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)

项目总结(总体)： 主要目标是建立一个多中心的超级老龄化联盟，以识别行为、健康、生物、 遗传、环境、社会经济、心理社会、解剖和神经病理因素与 超级老龄化。这些目标将通过一个有3个核心的组织结构来实现 (行政/生物统计学、临床/影像和生物医学/神经病理学)和2个研究项目。这个 该联盟将在位于伊利诺伊州、威斯康星州、密歇根州和佐治亚州的4个美国地点招募500名参与者， 和加拿大安大略省西南部的网站，重点是黑人超级老年人的注册和认知 具有相似人口学特征的平均老年对照组(对照组)。行政/生物统计核心将 提供治理和财政监督，保持科学诚信，并创建一个集中的生物统计和 数据库基础设施，以协调核心、站点和项目的目标和活动， 与国家安全局和校外合作者合作。临床/影像核心将标准化 统一的跨站点和多学科的SuperAger特征，简化招聘，包括 黑人参与者，在综合数据库中输入相关信息，支持共同注册项目 1，并鼓励合作企业，旨在了解促进超级老龄化的因素。这个 Biospecimen/神经病理学核心公司将收集和储存来自SuperAging的脑组织和血液产品 和对照病例，按优化程序进行。它将提供病理诊断，量化选定的 神经变性和神经元结构的标记物，协调血浆生物标记物的分析 阿尔茨海默氏症，并为合作研究提供标本。项目1将使用状态- 最先进的可穿戴技术，以获得日常生活过程中的实时测量来表征 与睡眠、体力活动、自主神经反应性和社会参与度相关的量化参数 确定超级老年人是否具有相对保存和定量测定的生理和 与对照相比，行为上的“复杂性”。项目2将使用转录、遗传和蛋白质图谱 检验这一假设的方法，即超级老年人将在他们的生命中表现出显著的分子差异 中枢和外周免疫和炎症系统参数与对照组和 阿尔茨海默病患者。通过识别有助于卓越记忆的神经生物学特征 老年表现，该联盟的结果将有助于分离促进成功认知的因素 衰老，也许还可以预防与年龄相关的大脑疾病，如阿尔茨海默氏症。

PROJECT SUMMARY (Overall): The primary goal is to establish a multicenter SuperAging Consortium to identify behavioral, health, biologic, genetic, environmental, socioeconomic, psychosocial, anatomic and neuropathologic factors associated with SuperAging. These goals will be achieved through an organizational structure with 3 Cores (Administrative/Biostatistics, Clinical/Imaging, and Biospecimen/Neuropathology) and 2 Research Projects. The Consortium will enroll 500 participants across 4 US Sites located in Illinois, Wisconsin, Michigan and Georgia, and the Canadian Site in Southwest, Ontario, with a focus on the enrollment of Black SuperAgers and Cognitively Average Elderly Controls with similar demographics (Controls). The Administrative/Biostatistics Core will provide governance and fiscal oversight, maintain scientific integrity, and create a centralized biostatistics and database infrastructure to harmonize the goals and activities of the Cores, Sites, and Projects, with each other, with the NIA and with extramural collaborators. The Clinical/Imaging Core will standardize criteria for the uniform cross-site and multidisciplinary characterization of SuperAgers, streamline recruitment including that of Black participants, enter relevant information in the comprehensive database, support co-enrollment into Project 1, and encourage collaborative ventures aiming to understand the factors that promote SuperAging. The Biospecimen/Neuropathology Core will collect and bank brain tissue and blood products from SuperAging and Control cases, according to optimized procedures. It will render pathological diagnoses, quantitate selected markers of neurodegeneration and neuronal structure, coordinate the analyses of plasma biomarkers for Alzheimer's disease, and make specimens available for collaborative investigations. Project 1 will use state-of- the-art wearable technology to obtain real-time measurements in the course of everyday life to characterize quantitative parameters related to sleep, physical activity, autonomic responsivity, and social engagement to determine whether SuperAgers have relatively preserved and quantitatively determined physiologic and behavioral `complexity' compared to Controls. Project 2 will use transcriptomic, genetic, and protein profiling approaches to test the hypothesis that SuperAgers will demonstrate significant molecular differences in their central and peripheral immune and inflammatory system parameters compared to matched Control and Alzheimer's disease participants. By identifying neurobiologic features that contribute to superior memory performance in old age, outcomes from this Consortium will help isolate factors that promote successful cognitive aging and perhaps also prevent age-related brain diseases such as Alzheimer's disease.