Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)

项目总结（总体）： 主要目标是建立一个多中心的超级老龄化联盟，以确定行为，健康，生物， 遗传、环境、社会经济、社会心理、解剖和神经病理因素与 超级衰老这些目标将通过三个核心的组织结构来实现 （行政/生物统计学，临床/成像，生物标本/神经病理学）和2个研究项目。的 联盟将在位于伊利诺伊州、威斯康星州、密歇根州和格鲁吉亚的4个美国研究中心招募500名参与者， 以及位于安大略西南部的加拿大研究中心，重点关注黑人超级老年人和认知能力 具有相似人口统计数据的平均老年人对照（对照）。行政/生物统计核心将 提供治理和财政监督，保持科学完整性，并建立一个集中的生物统计和 数据库基础设施，以协调核心、站点和项目的目标和活动， 与国家情报局和校外合作者合作临床/成像核心将标准化标准， 对超级老年人进行统一的跨地点和多学科定性，简化招聘，包括 黑人参与者，在综合数据库中输入相关信息，支持共同注册进入项目 1，鼓励旨在了解促进超级老龄化的因素的合作企业。的 生物标本/神经病理学核心将从SuperAging收集和储存脑组织和血液制品 并对照病例，按优化程序进行。它将呈现病理诊断，定量选择 神经变性和神经元结构的标志物，协调血浆生物标志物的分析， 阿尔茨海默氏病，并提供标本用于合作调查。项目1将使用状态- 最先进的可穿戴技术，可在日常生活中获得实时测量， 与睡眠、身体活动、自主反应和社会参与相关的定量参数， 确定SuperAgers是否具有相对保存和定量测定的生理和 与对照组相比，行为“复杂性”。项目2将使用转录组学、遗传学和蛋白质分析 方法来测试假设，超级老年人将表现出显着的分子差异， 与匹配对照相比的中枢和外周免疫和炎症系统参数， 老年痴呆症患者。通过识别有助于上级记忆的神经生物学特征 在老年表现，从这个联盟的结果将有助于隔离因素，促进成功的认知 也许还能预防与年龄有关的脑部疾病，如阿尔茨海默病。

PROJECT SUMMARY (Overall): The primary goal is to establish a multicenter SuperAging Consortium to identify behavioral, health, biologic, genetic, environmental, socioeconomic, psychosocial, anatomic and neuropathologic factors associated with SuperAging. These goals will be achieved through an organizational structure with 3 Cores (Administrative/Biostatistics, Clinical/Imaging, and Biospecimen/Neuropathology) and 2 Research Projects. The Consortium will enroll 500 participants across 4 US Sites located in Illinois, Wisconsin, Michigan and Georgia, and the Canadian Site in Southwest, Ontario, with a focus on the enrollment of Black SuperAgers and Cognitively Average Elderly Controls with similar demographics (Controls). The Administrative/Biostatistics Core will provide governance and fiscal oversight, maintain scientific integrity, and create a centralized biostatistics and database infrastructure to harmonize the goals and activities of the Cores, Sites, and Projects, with each other, with the NIA and with extramural collaborators. The Clinical/Imaging Core will standardize criteria for the uniform cross-site and multidisciplinary characterization of SuperAgers, streamline recruitment including that of Black participants, enter relevant information in the comprehensive database, support co-enrollment into Project 1, and encourage collaborative ventures aiming to understand the factors that promote SuperAging. The Biospecimen/Neuropathology Core will collect and bank brain tissue and blood products from SuperAging and Control cases, according to optimized procedures. It will render pathological diagnoses, quantitate selected markers of neurodegeneration and neuronal structure, coordinate the analyses of plasma biomarkers for Alzheimer's disease, and make specimens available for collaborative investigations. Project 1 will use state-of- the-art wearable technology to obtain real-time measurements in the course of everyday life to characterize quantitative parameters related to sleep, physical activity, autonomic responsivity, and social engagement to determine whether SuperAgers have relatively preserved and quantitatively determined physiologic and behavioral `complexity' compared to Controls. Project 2 will use transcriptomic, genetic, and protein profiling approaches to test the hypothesis that SuperAgers will demonstrate significant molecular differences in their central and peripheral immune and inflammatory system parameters compared to matched Control and Alzheimer's disease participants. By identifying neurobiologic features that contribute to superior memory performance in old age, outcomes from this Consortium will help isolate factors that promote successful cognitive aging and perhaps also prevent age-related brain diseases such as Alzheimer's disease.