HIV Prevention for the Mentally Ill: Motivation-Skills

精神病患者的艾滋病毒预防：动机技能

• 批准号: 7061898
• 负责人: STEPHEN MICHAEL BRADY
• 金额: $ 28.18万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7061898
• 关键词: AIDS education /prevention; behavioral /social science research tag; clinical research; communication; condoms; educational resource design /development; focus groups; health services research tag; high risk behavior /lifestyle; human immunodeficiency virus 1; human subject; interpersonal relations; mental disorders; mental health counseling; motivation; needle sharing; patient oriented research; safe sex /sex abstinence; substance abuse related behavior

DESCRIPTION (provided by applicant): People with serious mental illness (SMI) continue to be at high risk for HIV infection. Interventions designed to reduce this risk have been met with only modest success, suggesting a critical need for innovative approaches for this population. The proposed R34 exploratory study grant (a revision of an earlier application) will allow us to adapt and refine two manualized interventions for HIV risk reduction for people with SMI. Our primary aim is to develop a "real world" approach towards reducing HIV risk for this population, integrating recent advances in Motivational Interviewing and traditional Skills-Building interventions. Specifically, we will adapt existing HIV risk reduction Skills Building interventions, which have traditionally been administered in group formats, for use with individual patients. We will then incorporate Motivational Interviewing techniques into the Skills-Building intervention so that we will be able to compare the efficacy of each intervention (Skills-Building alone vs. an integrated Skills-Building and Motivational Interviewing intervention) in order to explore the degree to which integration of Motivational Interviewing techniques augment traditional Skills-Building interventions. Development of these interventions will be a central focus of this project, utilizing focus groups and advisory boards consisting of consumers and providers. Following the development phase of the project, we will pilot-test these interventions with an urban and disenfranchised sample of approximately 40 HIV-seropositive and seronegative men and women with serious mental illness, most of whom will be people of color. Participants will be randomly assigned to a brief, integrated Skills-Building-Motivational Interviewing intervention or to a standard Skills-Building intervention of the same duration and number of sessions. The degree to which these interventions are efficacious in reducing HIV risk behaviors and increasing skills in communication/negotiation and correct condom usage will also be examined. Participant characteristics most likely to predict outcome will also be identified. Another key and unique objective for this project is to examine the degree to which these interventions can be useful in facilitating HIV counseling and testing for people with SMI at risk for HIV. It is our expectation that this intervention refinement and pilot testing will provide us with the data and insight needed for a compelling larger-scale clinical trial, which we will pursue through the R01 mechanism.

描述（由申请人提供）：患有严重精神疾病（SMI）的人仍然处于艾滋病毒感染的高风险之中。旨在减少这一风险的干预措施只取得了一定的成功，这表明迫切需要为这一人群采取创新方法。拟议的R34探索性研究补助金（对早期申请的修订）将使我们能够调整和完善两种手动干预措施，以降低SMI患者的艾滋病毒风险。我们的主要目标是制定一个“真实的世界”的方法，以减少艾滋病毒的风险，为这一人群，整合动机面试和传统的技能建设干预措施的最新进展。具体而言，我们将调整现有的艾滋病毒风险降低技能建设干预措施，传统上以小组形式管理，用于个别患者。然后，我们将动机面试技术纳入技能建设干预，以便我们能够比较每种干预措施（单独的技能建设与综合技能建设和动机面试干预措施）的有效性，以探索动机面试技术的整合在多大程度上增强了传统的技能建设干预措施。制定这些干预措施将是该项目的中心重点，利用由消费者和供应商组成的重点小组和咨询委员会。在该项目的开发阶段之后，我们将对这些干预措施进行试点测试，其中包括约40名患有严重精神疾病的艾滋病毒血清反应阳性和血清反应阴性的城市和被剥夺公民权的男性和女性，其中大多数是有色人种。参与者将被随机分配到一个简短的，综合的技能建设动机面试干预或标准的技能建设干预相同的持续时间和会话数量。还将审查这些干预措施在减少艾滋病毒风险行为和提高沟通/谈判技能以及正确使用避孕套方面的有效程度。还将确定最有可能预测结果的参与者特征。该项目的另一个关键和独特的目标是研究这些干预措施在促进艾滋病毒咨询和检测的程度，为有艾滋病毒风险的重度精神障碍患者提供帮助。我们期望，这种干预措施的改进和试点测试将为我们提供一个引人注目的大规模临床试验所需的数据和见解，我们将通过R 01机制来实现这一目标。