Core--Cardiovascular Disease

核心--心血管疾病

• 批准号: 7525178
• 负责人: Steven Harold Kelder
• 金额: $ 11.3万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7525178
• 关键词: African American; Mexican Americans; biomedical facility; cardiovascular disorder; cardiovascular disorder epidemiology; cardiovascular disorder prevention; child (0-11); clinical research; community; epidemiology; health behavior; health disparity; human data; human subject; medical outreach /case finding; obesity; phenotype

PARENT ABSTRACT (CORE ABSTRACT NOT PROVIDED) The broad objective is to determine prevalence of obesity and type 2 diabetes in Hispanic adolescents. Relationships between these two health problems and factors that contribute to them will be analyzed. Besides providing information to design prevention interventions, this pilot will record baseline data before implementation of a comprehensive children's health program in the school system. After a cohort has encountered this program, the study can be repeated to evaluate its effects. The specific aims of the program are to obtain baseline data, to determine relationships between adiposity, biological markers of type 2 diabetes, behavioral and socioeconomic factors in the development of obesity, to suggest possible prevention interventions, and to use the data to evaluate current and future interventions. The study takes place in Brownsville, on the Texas Mexico border, where the population is 84.8% Hispanic. This community has an average income half that of the rest of the United States, but high disease burdens, particularly chronic diseases such as diabetes. The study population will consist of 474 9th to 12th grade students who are randomly selected. A Type I error level of 0.05, standard deviation of 6.4 BMI units will be assumed and 474 non-respondents will be interviewed. Height, weight, Body Impedance Analysis, blood pressure, acanthosis nigricans, fasting plasma glucose, insulin, lipid profile, C-reactive protein, liver function tests, demographic factors, physical activity and nutritional habits will be recorded. Results from these tests will be shared with the parents of the child. Summary measures (means, median, mode, variability measurements: standard deviation, range, interquartile range, etc.) will be determined. The data will be shared with the Cardiovascular Core for use in evaluation of the effectiveness of their interventions. The Statistical Economic Analysis Core (SEAC) will provide data analyses. A database will contain data from the clinical examination, questionnaire and laboratory. The findings will be analyzed to determine the prevalence of overweight and obese children, type 2 diabetes and association of risk factors. These analyses will be shared with other researchers at the HHRC, with the community, and used to design interventions. A second database will be built to enter data from the non-responder parents.

父母摘要（未提供核心摘要） 广泛的目标是确定西班牙裔青少年肥胖症和2型糖尿病的患病率。 将分析这两个健康问题与导致他们的因素之间的关系。 除了提供有关设计预防干预措施的信息外，该飞行员还将在实施学校系统中的全面儿童健康计划之前记录基线数据。 队列遇到该程序后，可以重复该研究以评估其效果。该计划的具体目的是获得基线数据，以确定肥胖发展中肥胖，2型糖尿病的生物学标志物，行为和社会经济因素之间的关系，建议可能的预防干预措施，并使用数据评估当前和未来的干预措施。 这项研究发生在布朗斯维尔的德克萨斯州墨西哥边境，那里的西班牙裔84.8％。这个社区的平均收入是美国其他地区的一半，但疾病高 负担，尤其是慢性疾病，例如糖尿病。研究人群将由474至12年级的学生组成，这些学生被随机选择。 I型错误级别为0.05，将假定为6.4 BMI单元的标准偏差，并将采访474个非响应者。身高，体重，身体阻抗分析，血压，棘皮动物鼻孔，空腹血糖，胰岛素，脂质谱，C反应蛋白，肝功能测试，人口统计学因素，身体活动和营养习惯将被记录。这些测试的结果将与孩子的父母共享。 将确定摘要度量（均值，中值，模式，可变性测量：标准偏差，范围，四分位间距等）。数据将与心血管核心共享，以评估其干预措施的有效性。统计经济分析核心（SAC）将提供数据分析。数据库将包含来自临床检查，问卷调查和实验室的数据。 这些发现将进行分析，以确定超重和肥胖儿童，2型糖尿病以及危险因素的关联的患病率。这些分析将与HHRC，社区的其他研究人员共享，并用于设计干预措施。将构建第二个数据库，以输入非反应者父母的数据。