SOUTH TEXAS PARENT DIABETES PREVENTION TRAIL (STPDPT)

拟议中的墨西哥裔美国人糖尿病卓越中心旨在开展 研究墨西哥裔美国人糖尿病及其并发症的生理进展， 制定糖尿病预防策略，测试有效干预的创新方法， 2型糖尿病患者中的少数群体。该中心提出了一个行政核心， 研究核心，包括三个研究项目和两个试点研究，一个培训核心和一个社区 参与核心。 作为研究核心的一部分，南德克萨斯州父母糖尿病预防试验（STPDPT）旨在测试 一个简短的动机增强访谈（MEI）治疗的有效性，旨在父母修改 家庭环境，使他们的孩子：a）减少“屏幕时间”或久坐不动的时间 行为; B）减少高热量，低营养食物的消费;和c）增加身体的水平 活动这些目标将通过将360名儿童随机分配到两种治疗条件之一来实现： 《En Vivo！基于MEI电话和互联网的父母治疗程序;和B）无治疗对照。我们 将检查选定的饮食，久坐和体育活动行为的积极变化是否会导致 2型糖尿病的发病机制有哪些？拟议项目将影响：a） 体重指数（BMI），B）C-反应蛋白（CRP），c）胰岛素抵抗，d）HbA 1c，以及e）行为 以及这些物理测量的社会心理前兆。家庭将被随机分配至STPDPT 条件或对照组;治疗组将接受6-9次MEI电话随访 在12个月的时间里，通过互联网、通讯和漫画书联系。研究目的：1）开展 与家长、教师和学生进行访谈，以确定MEI电话和互联网的总体可行性 父母糖尿病预防策略（Fall，2007）; 2）对200名父母进行横断面调查， 南德克萨斯州下格兰德河河谷，以扩展和确认目标1（2008年春季）的发现; 3） 利用试点数据为家长量身定制基于MEI的家长计划（2008年夏季）; 4）评估影响 基于MEI的父母项目，使用随机化的方法对9-14岁儿童的生理和行为结果进行研究 从卡梅隆成员中招募360个家庭（父母/子女二联体）的临床试验方法 县西班牙裔队列（秋季2008 - 2011）。

The proposed Center of Excellence on Diabetes in Americans of Mexican Descent aims to conduct research on the physiologic progression to diabetes and its complications among Mexican Americans, and to develop diabetes prevention strategies and test innovative approaches to effective interventions in a minority population severely affected by type 2 diabetes. This Center proposes an administrative core, a research core including three research projects and two pilot studies, a training core and a community engagement core. As part of the research core, the South Texas Parent Diabetes Prevention Trial (STPDPT) aims to test the effectiveness of a brief motivational enhanced interview (MEI) treatment aimed at parents to modify the home environment so that their children will: a) reduce "screen time" or hours engaged in sedentary behaviors; b) reduce consumption of high calorie, low nutrient foods; and c) increase levels of physical activity. These aims will be accomplished by randomizing 360 children to one of two treatment conditions: a) the En Vivo! MEI telephone and Internet based parent treatment program; and b) no-treatment control. We will examine if positive changes in selected dietary, sedentary and physical activity behaviors result in decreased weight gain and risk factors associated with type 2 diabetes. The proposed project will impact: a) body mass index (BMI), b) C-reactive protein (CRP), c) insulin resistance, d) HbA1c, as well e) behavioral and psychosocial precursors to these physical measures. Families will be randomized to the STPDPT condition or a comparison group; those in the treatment group will receive 6-9 MEI phone calls plus follow-up contact via the Internet and newsletters and comic books over a 12 month period. Study Aims: 1) To conduct interviews with parents, teachers, and students to determine overall feasibility of MEI telephone and Internet parent diabetes prevention strategies (Fall, 2007); 2) To conduct a cross sectional survey of 200 parents in the South Texas Lower Rio Grande Valley to extend and confirm findings from Aim 1 (Spring, 2008); 3) To use pilot data to tailor the MEI based parent program for parents (Summer 2008); 4) To assess the impact MEI based parent program on physiologic and behavioral outcomes on children aged 9-14 using randomized clinical trial methodology with 360 families (parent/child dyad) recruited from members of the Cameron County Hispanic Cohort (Fall 2008 - 2011).