Maternal Stress and Fetal/Infant Development

母亲压力与胎儿/婴儿发育

• 批准号: 7002665
• 负责人: CURT ALAN SANDMAN
• 金额: $ 56.33万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-23 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002665
• 关键词: behavior test; behavioral /social science research tag; blood tests; child behavior disorders; child physical development; developmental disease /disorder; developmental neurobiology; developmental psychology; female; human pregnant subject; human subject; hypothalamic pituitary adrenal axis; interview; longitudinal human study; neuromuscular system; outcomes research; patient oriented research; physiologic stressor; prenatal growth disorder; prenatal stress; psychological stressor; questionnaires; radioimmunoassay; social psychology; statistics /biometry; women' s health

Recent evidence indicates that the human fetus is exposed to profound influences that have permanent implications for health. Maternal stress initiates a cascade of events that alter normal developmental processes in the human fetus. Human fetuses exposed to elevated stress signals have impaired learning in utero and are at three-fold increased risk for preterm birth and low birth weight. Moreover, as many as one-half of the infants born early or small, have motor, sensory or cognitive handicaps. The primary aim of this five-year proposal is to determine the influence of prenatal maternal stress and maternal neuroendocrine responses on fetal behavior and to assess the relationship between fetal behavior and infant development in a sample of 200 women (one-half Anglo, one-half Hispanic). The specific aims are to: (a) Identify the primary stress factors that influence fetal behavior and (b) infant development. Stress will be measured (interviews and questionnaires) five times during pregnancy. Fetal behavior and development will be quantified by conventional measures of fetal growth and by measures of fetal behavioral state, movement (at rest and challenge), reactivity and habituation of fetal heart rate (FHR). Infant behavior will be assessed with the Bayley scales of Development, the Neuromotor Status Examination and by basal and circadian measures of hypothalamic-pituitary-adrenal (HPA) activity: (c) Determine the influence of maternal stress-related (HPA) axis activity and disregulation on fetal and infant behavior and infant HPA activity. Because maternal stress alters peptide receptors and brain peptide levels in the fetal rat brain and because it influences human fetal behavior and birth outcomes, maternal peptide levels will be assayed from blood obtained at each visit. The influence of maternal stress peptides on infant behavior and HPA activity will be determined at six weeks, six, twelve and twenty-four months. (d) Describe the relationship between fetal behavior and infant outcome. A sensitive measure of fetal CNS activity (habituation) will be integrated with contemporary measures of fetal behavior at rest and after challenge, to describe fetal maturation. These measures will be entered into models to predict infant neuromotor development. This project is designed to identify maternal stressful conditions that are harmful to the fetus by examination of the timing and duration of stress, by investigation of biological mechanisms related to prenatal stress, specifically the HPA and placental axis and by longitudinal studies of developmental consequences of prenatal stress in the infant.

最近的证据表明，人类胎儿暴露于对健康有永久影响的深刻影响。 母亲的压力引发了一系列改变人类胎儿正常发育过程的事件。 暴露于高压力信号的人类胎儿在子宫内的学习能力受损，早产和低出生体重的风险增加三倍。 此外，多达一半的早产儿或小婴儿有运动、感觉或认知障碍。 这项为期五年的提案的主要目的是确定产前母体压力和母体神经内分泌反应对胎儿行为的影响，并评估200名妇女（一半是英国人，一半是西班牙人）的样本中胎儿行为和婴儿发育之间的关系。 具体目标是：（a）确定影响胎儿行为的主要应激因素和（B）婴儿发育。 在怀孕期间，将对压力进行五次测量（访谈和问卷调查）。 将通过常规的胎仔生长测量和胎仔行为状态、运动（静息和激发时）、反应性和胎仔心率（FHR）习惯性测量来量化胎仔行为和发育。婴儿行为将用Bayley发育量表、神经运动状态检查和通过下丘脑-垂体-肾上腺（HPA）活性的基础和昼夜测量来评估：（c）确定母体应激相关（HPA）轴活性和失调对胎儿和婴儿行为以及婴儿HPA活性的影响。 由于母体应激改变胎鼠脑中的肽受体和脑肽水平，并且由于其影响人胎行为和出生结局，因此将从每次访视时获得的血液中测定母体肽水平。 在6周、6个月、12个月和24个月时测定母体应激肽对婴儿行为和HPA活性的影响。(d)描述胎儿行为和婴儿结局之间的关系。 将胎仔CNS活动（习惯化）的灵敏测量与静息和激发后胎仔行为的当代测量相结合，以描述胎仔成熟。 这些措施将进入模型，以预测婴儿神经运动发育。 该项目旨在通过检查压力的时间和持续时间，通过调查与产前压力有关的生物机制，特别是HPA和胎盘轴，以及通过对产前压力对婴儿发育后果的纵向研究，确定对胎儿有害的母亲压力状况。

项目成果

Development of white matter pathways in typically developing preadolescent children.

• DOI: 10.1016/j.brainres.2012.05.035
• 发表时间: 2012-07-23
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Muftuler LT;Davis EP;Buss C;Solodkin A;Su MY;Head KM;Hasso AN;Sandman CA
• 通讯作者: Sandman CA

Maturation of the human fetal startle response: evidence for sex-specific maturation of the human fetus.

• DOI: 10.1016/j.earlhumdev.2009.08.001
• 发表时间: 2009-10
• 期刊: EARLY HUMAN DEVELOPMENT
• 影响因子: 2.5
• 作者: Buss, Claudia;Davis, Elysia Poggi;Class, Quetzal A.;Gierczak, Matt;Pattillo, Carol;Glynn, Laura M.;Sandman, Curt A.
• 通讯作者: Sandman, Curt A.

Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.

• DOI: 10.1002/dev.20510
• 发表时间: 2011-03
• 期刊: Developmental psychobiology
• 影响因子: 2.2

Eye of the beholder? Maternal mental health and the quality of infant sleep.

• DOI: 10.1016/j.socscimed.2012.07.006
• 发表时间: 2013-02
• 期刊: SOCIAL SCIENCE & MEDICINE
• 影响因子: 5.4
• 作者: Goldberg, Wendy A.;Lucas-Thompson, Rachel G.;Germo, Gary R.;Keller, Meret A.;Davis, Elysia Poggi;Sandman, Curt A.
• 通讯作者: Sandman, Curt A.

Low levels of corticotropin-releasing hormone during early pregnancy are associated with precocious maturation of the human fetus.

• DOI: 10.1159/000191213
• 发表时间: 2008
• 期刊: Developmental neuroscience
• 影响因子: 2.9
• 作者: Class QA;Buss C;Davis EP;Gierczak M;Pattillo C;Chicz-DeMet A;Sandman CA
• 通讯作者: Sandman CA