NERVOUS SYSTEM DEVELOPMENT AND INJURY

描述(由申请人提供) 本申请寻求继续为以下两个培训方案提供资金： 华盛顿大学，这所大学一直由 神经内科和神经外科在过去的19年里，以及 另一种是由儿科神经科实施的 过去的八年里。后者，神经科学学者 发展奖，不能续签。我们寻求提供一个扩展的计划 为选定的学员提供神经学、神经外科或 儿科神经学，为学术生涯做准备。利用，利用 翻译神经科学研究的进展在过去的几年里，我们 我们的培训计划更加强调以病人为本 研究。因此，我们打算加强我们历史上对板凳研究的重视 通过为我们的学员提供在以下领域获得严格教育的机会 临床研究方法。我们相信，临床的下一步进展 神经学和神经外科将由研究人员进行实践， 在这种方法中，将临床专业知识与正规教育相结合。实习生 参加我们的培训计划预计将至少投入两个 除了住院医师培训之外，还需要多年的近乎全职的努力来完成这项任务。这是 可能是培养受过科学训练的人所需的最短时间 神经科或神经外科临床医生，对于阐明 神经系统疾病的发病机制，并带来新的治疗方法 病人。尽管加快了神经科学研究的进展，但 目前神经科或神经外科严重短缺 内科医生--有能力完成这些任务的科学家或临床研究人员 基本的翻译功能。事实上，美国神经病学 协会目前列出了150多个神经病学学术职位空缺 独自一人。 利用当前的优势，无论是在培训单位内部 (神经学、神经外科和儿科神经病学)，以及在更大的 华盛顿大学神经科学界，拟议的项目将 继续关注两个主要主题：神经系统损伤和紧张 系统开发。这两个主题是与疾病相关的活跃前沿 今天的神经科学，与理解许多 不同的神经系统疾病。这些主题是互补的，也是 部分重叠。对发展中的本质的洞察 神经系统很可能与了解神经系统有关 对伤害的反应。

DESCRIPTION (provided by applicant) The present application seeks continued funding for two training programs at Washington University, one that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 19 years, and another that has been administered by the Division of Pediatric Neurology for the past eight years. The latter, the Neurological Sciences Academic Development Award, cannot be renewed. We seek to provide a program of extended research training for selected trainees in Neurology, Neurosurgery, or Pediatric Neurology, preparing for academic careers. To take advantage of progress in translational neuroscience research over the last few years, we have increased the emphasis of our training program on patient-oriented research. We thus intend to augment our historical emphasis on bench research by offering our trainees the opportunity to gain a rigorous education in clinical research methodology. We believe that the next advances in clinical neurology and neurosurgery will be brought into practice by investigators who combine clinical expertise with formal education in this methodology. Trainees participating in our training program will be expected to devote at least two years of near full-time effort beyond residency training to the task. This is likely the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinicians who will be essential for elucidating the pathogenesis of nervous system diseases, and bringing new therapies to patients. Despite accelerating neuroscience research advances, there is presently a serious shortage of neurological or neurosurgical physician-scientists or clinical researchers capable of performing these essential translational functions. Indeed, the American Neurological Association currently lists over 150 open positions in academic neurology alone. Exploiting current strengths, both within the training units themselves (Neurology, Neurosurgery, and Pediatric Neurology), and within the larger neuroscience community at Washington University, the proposed program will continue to focus on two major themes: Nervous System Injury, and Nervous System Development. These twin themes are active fronts in disease-related neuroscience today, relevant to understanding the pathogenesis of many different neurological diseases. These themes are complementary, as well as partially overlapping. Insights gained into the nature of the developing nervous system are highly likely to be relevant to understanding nervous system responses to injury.