Healthy Hearts Across Generations

代代相传的健康心脏

• 批准号: 7209595
• 负责人: KARINA L. WALTERS
• 金额: $ 40.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7209595
• 关键词: Native Americans; adolescence (12-20); age difference; behavior modification; behavioral /social science research tag; body composition; cardiovascular disorder prevention; cardiovascular disorder risk; clinical research; clinical trials; coping; disease /disorder proneness /risk; family genetics; focus groups; handbook; health behavior; health surveys; human subject; human therapy evaluation; information dissemination; interview; longitudinal human study; medically underserved population; middle childhood (6-11); parents; questionnaires; stress; videotape /videodisc

DESCRIPTION (provided by applicant): Northwest American Indians are a drastically understudied and underserved group, at risk for multiple health problems, in particular, cardiovascular disease. American Indians living in the Northwest have very high rates of diabetes, obesity, tobacco use, and other risk factors associated with cardiovascular disease. This application, in response to RFA HL-06-002, involves a 5-year developmental project to design and test a culturally appropriate, feasible, and generalizable cardiovascular disease risk prevention program for American Indians living in the Northwest. Building upon solid preliminary epidemiological and surveillance data as well as tribal support and an Indigenist stress-coping model, this study proposes five innovative and significant aims. First, we will conduct qualitative formative research involving 4 focus groups and 20, key informant interviews with parents aged 18-55 at risk for CVD, Native health providers, elder/traditional healers, and Native youth at long-term risk for CVD (aged 15-25). Second, we will conduct structured survey interviews with 375 American Indian adults randomly sampled from the Tulalip tribal rolls. With these interview data, we will test an indigenist stress coping model and establish preliminary baseline prevalence rates for self-reported CVD and its correlates with preliminary CVD and CVD risk-prevalence rates. Third, we will develop, manualize, and pilot test the feasibility, acceptability, and preliminary efficacy of a culturally-based 4-month CVD prevention intervention targeting adult American Indian parents at risk for CVD. Fourth, we will conduct a randomized control trial (RCT) of a multi-level motivational CVD intervention with 240 at-risk parents or caregivers of children under the age of 18 to evaluate its efficacy. We will also measure BMI on 480 children (age 5-18) whose parents or caregivers are in the RCT. Fifth, we will translate and disseminate the findings to the tribe as well as research outlets and the scientific community and prepare translational materials for community consumption and implementation. Through the course of the study, we aim to develop the research infrastructure at Tulalip Indian health clinic and to build the research capacity of the tribal community.

描述（由申请人提供）： 西北美洲印第安人是一个大量研究和服务不足的群体，有多种健康问题的风险，尤其是心血管疾病。居住在西北地区的美洲印第安人的糖尿病，肥胖症，烟草使用和与心血管疾病相关的其他危险因素的发生率很高。该应用程序响应RFA HL-06-002，涉及一个为期5年的开发项目，该项目针对居住在西北地区的美洲印第安人设计和测试适合文化，可行和可推广的心血管疾病风险预防计划。本研究以稳定的初步流行病学和监视数据以及部落支持以及土著主义压力的模型为基础，提出了五个创新和重要的目标。首先，我们将进行定性的形成性研究，涉及4个焦点小组和20个关键的线人访谈，与18-55岁的父母面临CVD风险，本土健康提供者，老年/传统治疗师和与CVD长期风险（15-25岁）的长期风险的原住民青年。其次，我们将对从图拉利普部落劳斯莱斯（Tulalip Tribal Lolls）随机抽样的375名印度成年人进行结构化的调查访谈。借助这些访谈数据，我们将测试一个本土主义压力应对模型，并为自我报告的CVD建立初步的基线患病率及其与初步的CVD和CVD风险阳性率相关。第三，我们将开发，手动化和试点测试基于文化的4个月CVD预防干预措施的可行性，可接受性和初步疗效，以面向成年美洲印第安人父母有CVD风险。第四，我们将对240名高危父母或18岁以下的儿童进行多层次动机干预措施进行随机对照试验（RCT），以评估其疗效。我们还将对480名儿童（5-18岁）的BMI进行测量，他们的父母或照料者处于RCT中。第五，我们将把发现并将其转换给部落，研究渠道和科学界，并为社区消费和实施准备转化材料。通过研究过程，我们旨在在图拉利普印度卫生诊所开发研究基础设施，并建立部落社区的研究能力。