ACT 3: RESOURCE CENTER FOR CELL IMAGE ANALYSIS

第 3 步：细胞图像分析资源中心

• 批准号: 7336040
• 负责人: ANNABELL C SEGARRA
• 金额: $ 4.45万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336040
• 关键词: AIDS; drug abuse; ephrins; fasting; microscopy; molecular /cellular imaging; regeneration; renin; sectioning; sex; tissues; training; university; workshop

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Image Analysis Resource Center (IARC) of the Medical Sciences Campus of the University of Puerto Rico was established in 1996. A previous instrumentation grant from the Department of Defense in 1993 provided the basic equipment. From 1996-2001 RCMI provided funds to purchase additional equipment and also technical support to train investigators in the use of Image Analysis and to supervise the facilities. The main objective of this second cycle of funding was to extend the current facilities to make them available to a larger population of investigators and to transform the Image Analysis into a facility that would be self sufficient after five years. The specific aims of this activity were: (1) To provide the infrastructure necessary so that researchers can use image analysis to quantify data in a fast and efficient manner. 2) To add additional capabilities to the IARC, such as confocal microscopy, and a vibratome to obtain thicker tissue sections for viewing under the confocal microscope. 3) To widely idstribute and disseminate image analysis technology by introducing investigators to the free imaging solftware "NIH Image", offering workshops and training investigators on the MCID and NIH imaging software packages. 4) To convert the current IARC into a self-supporting unit. Originally, five investigators were identified, who had projects with immediate need for high quality Image Analysis. These investigators had active funding for their research or had recently submitted grant applicadtions to federal funding agencies and are awaiting a decision. Their research areas were: The renin-antiotensin system and cardiomyopathy, sex steroids and neuropsychiatric disorders, AIDS and sensory myopathies, ephrins and nerve regeneration, motivational aspects of drug abuse.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。波多黎各大学医学院的图像分析资源中心（IARC）成立于1996年。1993年国防部提供的一笔仪器赠款提供了基本设备。从1996年至2001年，区域医学委员会提供资金购买更多的设备，并提供技术支助，培训调查人员使用图像分析和监督设施。第二个供资周期的主要目标是扩大现有设施，使更多的调查人员能够使用这些设施，并将图像分析中心改造成一个五年后能够自给自足的设施。 这项活动的具体目标是：（1）提供必要的基础设施，使研究人员能够使用图像分析，以快速和有效的方式量化数据。2)为IARC增加额外的功能，如共聚焦显微镜和振动切片机，以获得更厚的组织切片，以便在共聚焦显微镜下观察。3)通过向研究人员介绍免费的成像软件“NIH Image”，提供MCID和NIH成像软件包的研讨会和培训，广泛识别和传播图像分析技术。4)将目前的国际癌症研究机构转变为一个自我维持的单位。 最初，确定了五名研究人员，他们的项目迫切需要高质量的图像分析。这些研究人员有积极的研究资金，或最近向联邦资助机构提交了赠款申请，正在等待决定。他们的研究领域是：肾素-抗血管紧张素系统与心肌病，性类固醇与神经精神疾病，艾滋病与感觉性肌病，肝配蛋白与神经再生，药物滥用的动机方面。