ACTIVITY 1: MOLECULAR NEUROBIOLOGY UNIT

活动 1：分子神经生物学单元

• 批准号: 7336038
• 负责人: CONCHITA ZUAZAGA
• 金额: $ 8.89万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336038
• 关键词: gene expression; neurobiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this proposal was to expand the capability of investigators at the Institute of Neurobiology for carrying out research on the regulation of gene expression in neurobiological systems. The thrust of this expansion was to develop a molecular neurobiology unit at the Institute. Specifically, the aims of this proposal were to : 1) obtain the equipment required for carrying out this kind of research, and 2) provide salary support for one senior postdoctoral level investigator. The requested euipment and personnel were used to expand the following on-going projects by resident scientists: 1) molecular mechanisms that underlie A-current diversity in a lobster motor system, 2) molecular determinants of protein kinase A modulation of heart sodium channels, 3) role of engrailed paralogues in specification of neuronal anatomy and synaptic connections, 4) the crayfish myomodulin neuropeptides: precursor organization and gene expression, 5) amine receptor gene expression and status in the dominance hierarchies of a tropical prawn, and 6) changes in gene expression induced by basic fibroblast growth factor after optic nerve injury. The addition of a molecular neurobiology unit to study the structure, function or expression of specific neural proteins would significantly enhance the overall research capacity and opportunities for scientific training at the Institute. Although these studies are basic in nature, they addressed important molecular mechanisms that are critical for understanding neurological conditions affecting the Puerto Rican population

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该提案的长期目标是扩大神经生物学研究所的研究人员的能力，以研究神经生物学系统中基因表达的调节。这种扩展的推力是在研究所开发一个分子神经生物学单元。具体而言，该提案的目的是：1）获得进行此类研究所需的设备，2）为一名高级博士后研究员提供工资支持。 The requested euipment and personnel were used to expand the following on-going projects by resident scientists: 1) molecular mechanisms that underlie A-current diversity in a lobster motor system, 2) molecular determinants of protein kinase A modulation of heart sodium channels, 3) role of engrailed paralogues in specification of neuronal anatomy and synaptic connections, 4) the crayfish myomodulin神经肽：前体组织和基因表达，5）胺受体基因的表达和热带大虾的优势层次结构的状态，以及6）光神经损伤后碱性成纤维细胞生长因子诱导的基因表达的变化。增加分子神经生物学单元来研究特定神经蛋白的结构，功能或表达将显着增强研究所的总体研究能力和科学培训的机会。尽管这些研究本质上是基本的，但它们解决了重要的分子机制，这些机制对于理解影响波多黎各人群的神经系统疾病至关重要