CENTER FOR MOLECULAR, DEVELOPMENTAL AND BEHAVIORL NEURO

为了响应RNA #RR-00-003，题为生物医学研究卓越中心（COBRE），波多黎各大学（UPR）提交了题为分子发育和行为神经科学中心的多学科申请。这一建议是普遍定期审议全系统倡议的一部分，目的是根据卡内基分类将该机构列入研究I类。联合国大学正在其创建多校区和多学科研究所的倡议下，培育和促进这些全系统努力的形成。COBRE建议可作为发展其中一个研究所的基础。该提案的主要目标是：1）创建一个具有竞争力的神经科学研究中心，优化普遍定期审议系统在全国范围内竞争的能力，2）在中心主任的领导下和外部咨询委员会的科学指导下，将年轻科学家培养为具有竞争力的RO 1研究人员; 3）扩大波多黎各神经科学研究的能力。拟议的合作研究项目的目标是推进对神经元损伤、情感记忆、可卡因寻求行为和母性行为表达的分子机制的科学理解。这些目标和目的将通过以下方式实现：1）聘请神经科学领域的知名研究人员为中心提供领导和指导; 2）聘请另外三名有竞争力的研究人员，以培养公关方面的神经科学能力; 3）为发展中的年轻教师提供支持和培育环境（在管理部门的全力支持下）。咨询委员会由爱德华·A·Kravitz是哈佛医学院神经生物学的乔治帕克贝瑞教授，他将为UPR神经科学的发展和RO 1研究人员的发展提供科学指导。该大学将提供资源（250万美元的直接匹配资金加上四个专业线），用于招聘和雇用永久中心主任和三名新科学家，并为他们提供必要的启动资金，以帮助他们建立实验室。

In response to RNA #RR-00-003, entitled Centers of Biomedical Research Excellence (COBRE), the University of Puerto Rico (UPR) submits this multi-disciplinary application entitled Center for Molecular Developmental and Behavioral Neuroscience. This proposal is part of a UPR systemwide initiative to move the institution into the Research I category according to the Carnegie Classification. The University is nurturing and promoting the formation of these systemwide efforts under its initiative to create Multi-campus and Multi-disciplinary Research Institutes. The COBRE proposal could serve as the foundation for the development of one of these institutes. The prime objectives of this proposal are to: 1) create a competitive research center in neuroscience that will optimize the capacity of the UPR system to compete nationally, 2) develop young scientists into competitive RO1 researchers under the leadership of a Center Director and the scientific guidance of an External Advisory Committee; and 3) expand the capacity of a neuroscience research in Puerto Rico. The goals of the proposed collaborative research projects are to advance the scientific understanding of the molecular mechanisms underlying neuronal injury, emotional memory, cocaine- seeking behavior, and the expression of maternal behavior. These goals and objectives will be achieved by: 1) hiring an established researcher in the field of neuroscience to provide leadership and guidance to the Center; 2) hiring three additional competitive researchers to develop a cadre of neuroscience competency in PR; and 3) providing a supportive and nurturing environment (with the full backing of the administration) for the developing young faculty. The Advisory Committee, chaired by Dr. Edward A. Kravitz, George Packer Berry Professor of Neurobiology at the Harvard School of Medicine, will provide scientific guidance for the development of a strong thrust in neuroscience at UPR and the development of RO1 researchers. The University will provide the resources ($2.5 M in direct match funds plus four professional lines) for recruiting and hiring the Permanent Center Director and three new scientists and provide them the necessary startup funds to help them establish their laboratories.