CENTER FOR MOLECULAR, DEVELOPMENTAL AND BEHAVIORL NEURO

为响应题为生物医学研究卓越中心(COBRE)的RNA#RR-00-003，波多黎各大学(UPR)提交了这份题为分子发育和行为神经科学中心的多学科申请。这项提议是普遍定期审议全系统倡议的一部分，目的是根据卡内基分类将该机构列入研究一类。根据其创建多校区和多学科研究所的倡议，该大学正在培育和促进这些全系统努力的形成。科布雷的提议可以作为其中一个研究所发展的基础。这项建议的主要目标是：1)创建一个具有竞争力的神经科学研究中心，以优化普遍定期审议系统在全国竞争的能力；2)在中心主任的领导和外部咨询委员会的科学指导下，将年轻科学家培养成具有竞争力的RO1研究人员；以及3)扩大波多黎各神经科学研究的能力。拟议的合作研究项目的目标是促进对神经元损伤、情感记忆、寻求可卡因行为和母体行为表达的分子机制的科学理解。这些目标和目的将通过以下方式实现：1)聘请一名神经科学领域的资深研究人员为中心提供领导和指导；2)额外聘请3名有竞争力的研究人员，以培养一支神经科学公关能力骨干队伍；以及3)为发展中的年轻教员提供支持和培育的环境(在政府的全力支持下)。咨询委员会由哈佛医学院乔治·帕克·贝里神经生物学教授爱德华·A·克拉维茨博士担任主席，将为普遍定期审议神经科学领域的发展和RO1研究人员的发展提供科学指导。该大学将提供资源(250万美元的直接匹配资金和四条专业线路)，用于招聘和聘用永久中心主任和三名新科学家，并为他们提供必要的启动资金，帮助他们建立实验室。

In response to RNA #RR-00-003, entitled Centers of Biomedical Research Excellence (COBRE), the University of Puerto Rico (UPR) submits this multi-disciplinary application entitled Center for Molecular Developmental and Behavioral Neuroscience. This proposal is part of a UPR systemwide initiative to move the institution into the Research I category according to the Carnegie Classification. The University is nurturing and promoting the formation of these systemwide efforts under its initiative to create Multi-campus and Multi-disciplinary Research Institutes. The COBRE proposal could serve as the foundation for the development of one of these institutes. The prime objectives of this proposal are to: 1) create a competitive research center in neuroscience that will optimize the capacity of the UPR system to compete nationally, 2) develop young scientists into competitive RO1 researchers under the leadership of a Center Director and the scientific guidance of an External Advisory Committee; and 3) expand the capacity of a neuroscience research in Puerto Rico. The goals of the proposed collaborative research projects are to advance the scientific understanding of the molecular mechanisms underlying neuronal injury, emotional memory, cocaine- seeking behavior, and the expression of maternal behavior. These goals and objectives will be achieved by: 1) hiring an established researcher in the field of neuroscience to provide leadership and guidance to the Center; 2) hiring three additional competitive researchers to develop a cadre of neuroscience competency in PR; and 3) providing a supportive and nurturing environment (with the full backing of the administration) for the developing young faculty. The Advisory Committee, chaired by Dr. Edward A. Kravitz, George Packer Berry Professor of Neurobiology at the Harvard School of Medicine, will provide scientific guidance for the development of a strong thrust in neuroscience at UPR and the development of RO1 researchers. The University will provide the resources ($2.5 M in direct match funds plus four professional lines) for recruiting and hiring the Permanent Center Director and three new scientists and provide them the necessary startup funds to help them establish their laboratories.