DRUG DISCOVERY RESEARCH CORE: AIDS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。关于艾滋病，药物发现研究(DDR)的总体目标是通过集中协调的研究协作，加强佛罗里达农工大学药物发现的研究基础结构。尽管化疗药物及其作用机制有了重大发现，但对具有新作用机制的新化学实体的需求仍然很高，以治疗某些癌症和传染病。因此，通过研究合作，计划积极开发新的代理及其作用机制。这项活动的另一个推动力是朝着补救参与药物发现研究的少数族裔研究人员数量的持续差异迈出了一步。将药物发现研究植入历史上的黑人学院和大学之所以困难，是因为缺乏足够的资源、训练有素的研究人员和药物发现的研究基础设施。为了实现这一目标，DDR制定了以下五个具体目标，以增加这一应用中的药物发现研究活动：加强药物发现研究合作活动；建立核心分析仪器实验室；加强基于计算机的分子模拟实验室；增加少数群体研究人员并支持药物发现领域的先导研究项目。这些活动的预期结果是通过研究人员之间的合作和共享有限的资源，对大学整体研究产生积极影响，并提高教师研究的竞争力。该大学还预计，少数族裔研究人员的数量将增加，发表成果的效率将提高，从而增加研究资金机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS The overall goal of the Drug Discovery Research (DDR) is to strengthen the research infra-structure for drug discovery at Florida A&M University through research collaboration in a focused and coordinated effort. Despite significant discovery of chemotherapeutic agents and their mechanisms of action, the need for new chemical entities having new mechanisms of action for the treatment of certain cancer and infectious diseases remain high. Therefore, an aggressive exploitation of new agents and their action mechanism is planned through research collaboration. Another impetus for this activity is to take a step toward a remedy for the persistent disparity in the number of minority investigators involved in drug discovery research. The difficulty in implanting drug discovery research at historically black colleges and universities is due to the lack of adequate resources, trained investigators and research infrastructure for drug discovery. To realize this goal, the DDR has developed the following five specific aims to increase drug discovery research activities in this application: enhance drug discovery research collaboration activities; establish a core analytical instrument laboratory; augment computer-based molecular modeling laboratory; increase minority investigators and support pilot research projects in the area of drug discovery. The expected outcomes of these activities are the positive impact on university research in ecumenical and increased faculty research competitiveness through collaboration and sharing of limited resources among the investigators. The University also expects an increased number of minority researchers and productivity in publishing results that lead to an increase in research funding opportu