fMRI studies of motivation and executive function

动机和执行功能的功能磁共振成像研究

• 批准号: 7114563
• 负责人: DANIEL CHARLES KRAWCZYK
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114563
• 关键词: amygdala; behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; executive function; functional magnetic resonance imaging; human subject; motivation; negative reinforcements; neural information processing; neuropsychology; neuroregulation; postdoctoral investigator; prefrontal lobe /cortex; reinforcer; short term memory; tegmentum; visual cortex

DESCRIPTION (provided by applicant): This proposal focuses on the way reward and motivation are linked to executive function. Reward representation and working memory are key functions of the prefrontal cortex (PFC), but their interactions are not well understood at the neural systems level. This line of fMRI experiments will test fundamental assumptions about the way motivation and performance are represented in the brain. All experiments use variations of a working memory task requiring the maintenance of faces or scenes that has been shown to recruit PFC and posterior visual areas (PPA and FFA). Specifically, I will test whether manipulations of reward value recruit separable, or additional PFC regions and whether modulations in posterior visual areas can be altered by higher motivation trials. A second experiment will investigate financial punishment trials to assess the differences that may exist in a non-rewarded motivation manipulation. Analyses will include whole-brain, ROI, and correlational approaches to assess the activation differences based on varying reward motivation in the task. I will also include a modified task that will allow for superior modeling of the task periods. Overall, this research will clarify the functional organization of working memory and motivation.

描述（由申请人提供）：该提案重点介绍了奖励和动机与执行功能有关的方式。奖励表示和工作记忆是前额叶皮层（PFC）的关键功能，但是在神经系统层面上，它们的相互作用尚未得到很好的了解。 FMRI实验线将测试有关大脑中动机和表现方式的基本假设。所有实验都使用工作记忆任务的变体，这些任务需要维护面部或场景，这些面孔或场景已被证明募集了PFC和后视觉区域（PPA和FFA）。具体而言，我将测试是否可以通过更高的动机试验来改变对奖励价值募集的可分离或其他PFC区域以及后视觉区域的调制。第二个实验将调查财务惩罚试验，以评估非奖励动机操纵中可能存在的差异。分析将包括全脑，ROI和相关方法，以根据任务中的奖励动机来评估激活差异。我还将包括一个修改后的任务，该任务将允许对任务阶段进行卓越的建模。总体而言，这项研究将阐明工作记忆和动力的功能组织。