GENOTOXIC EFFECTS IN RATS

对大鼠的基因毒性作用

• 批准号: 7336108
• 负责人: ANITA K PATLOLLA
• 金额: $ 1.58万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336108
• 关键词: GENOTOXIC; EFFECTS; RATS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Arsenic is a well-established human carcinogen and is ubiquitous in low concentration virtually in all the environment media. Acute exposure to arsenic trioxide has been reported to induce death and/or multiple organ damage with symptoms including nausea, vomiting, diarrhea, gastrointestinal hemorrhage, cerebral edema, tachycardia, dysrhythmias, and hypovolemic shock. Although epidemiological data have firmly established inorganic arsenic to be a human carcinogen, animal studies are less well defined. The carcinogenicity of inorganic arsenic in animals, primarily rodents, has been the subject of debate due to the limited data set, the perceived inadequacy in the design of some of the earlier studies and its genotoxicity that has not been fully characterized

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。砷是一种公认的人类致癌物，几乎在所有环境介质中以低浓度普遍存在。据报道，急性暴露于三氧化二砷可诱导死亡和/或多器官损伤，症状包括恶心、呕吐、腹泻、胃肠道出血、脑水肿、心动过速、心律失常和低血容量性休克。虽然流行病学数据已经确定无机砷是一种人类致癌物，但动物研究的定义不太明确。无机砷对动物（主要是啮齿动物）的致癌性一直是争论的主题，这是由于数据集有限，一些早期研究的设计被认为是不充分的，而且其遗传毒性尚未得到充分表征