GENOTOXIC EFFECTS IN RATS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Arsenic is a well-established human carcinogen and is ubiquitous in low concentration virtually in all the environment media. Acute exposure to arsenic trioxide has been reported to induce death and/or multiple organ damage with symptoms including nausea, vomiting, diarrhea, gastrointestinal hemorrhage, cerebral edema, tachycardia, dysrhythmias, and hypovolemic shock. Although epidemiological data have firmly established inorganic arsenic to be a human carcinogen, animal studies are less well defined. The carcinogenicity of inorganic arsenic in animals, primarily rodents, has been the subject of debate due to the limited data set, the perceived inadequacy in the design of some of the earlier studies and its genotoxicity that has not been fully characterized