Fast OCT technology for comprehensive diagnostic imaging

用于全面诊断成像的快速 OCT 技术

基本信息

批准号：
7107962
负责人：
JOHANNES F DE BOER
金额：
$ 57.08万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-15 至 2008-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7107962
关键词：
Barretts esophagus adult human (21+)atherosclerotic plaque bioimaging /biomedical imaging cardiovascular disorder diagnosis cardiovascular imaging /visualization clinical research early diagnosis electrocardiography endoscopy esophagus neoplasm eye disorder diagnosis gastrointestinal disorder diagnosis gastrointestinal imaging /visualization glaucoma human subject optical tomography technology /technique development

项目摘要

DESCRIPTION (provided by applicant): Over the past 10 years, optical coherence tomography (OCT) has undergone a rapid development from inception to a versatile method for non-invasive high-resolution optical imaging. A wide range of medical diagnostic applications has been explored in ophthalmology, cardiology and in early cancer diagnosis in general. Preliminary studies have demonstrated that OCT can facilitate the accurate diagnosis of a variety of diseases when used in a point-sampling protocol analogous to random biopsy. The potential diagnostic applications having the highest impact, however, require screening or surveillance of large tissue volumes. The relatively slow image acquisition rate of current OCT technology therefore represents a significant barrier to its utility as a powerful clinical tool. Since the current technology commonly operates at its theoretical limit for efficient light collection, dramatic improvements in imaging speed can only be obtained through a technological paradigm shift. We propose to develop a new, parallel detection principle for OCT that is several hundred-fold more efficient than current state of the art technology and that provides vastly improved image acquisition rate and resolution. The system design of the proposed technology is tailored to three high-impact clinical goals: early detection and monitoring of glaucoma, the second-leading cause of blindness in the U.S, detection and characterization of vulnerable coronary plaques responsible for acute myocardial infarction, and comprehensive surveillance for esophageal neoplasia in patients with Barrett's esophagus. Three clinical pilot studies, using technology developed in this work, will be conducted to test system performance relevant to achieving these goals.

描述（由申请人提供）：在过去的10年中，光学相干断层扫描（OCT）经历了从诞生到非侵入性高分辨率光学成像的多功能方法的迅速发展。在眼科，心脏病学和早期癌症诊断中，已经探索了广泛的医学诊断应用。初步研究表明，在与随机活检类似的点采样方案中使用时，OCT可以促进各种疾病的准确诊断。但是，潜在的诊断应用具有最大的影响，需要对大组织容量进行筛查或监视。因此，当前OCT技术的图像采集率相对较慢，这是其作为强大临床工具的实用性的重大障碍。由于当前的技术通常以其有效的光收集的理论限制运行，因此仅通过技术范式转移才能获得成像速度的显着提高。我们建议为OCT开发一种新的，并行的检测原理，该原则比当前技术的现状高出几百倍，并提供了大大改善的图像采集率和分辨率。拟议技术的系统设计是针对三个高影响临床目标量身定制的：青光眼的早期检测和监测是美国失明的第二个领先原因，对负责急性心肌梗死的脆弱冠状动脉斑块的检测和表征，以及对贝洛氏菌群患者的全面监测以及全面的监测。使用这项工作中开发的技术，将进行三项临床试点研究，以测试与实现这些目标有关的系统性能。