Video Rate OCT for Evaluating Glaucoma

用于评估青光眼的视频速率 OCT

• 批准号: 6878966
• 负责人: JOHANNES F DE BOER
• 金额: $ 47.75万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6878966
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; blindness; clinical research; diagnosis design /evaluation; digital imaging; disease /disorder prevention /control; early diagnosis; eye disorder diagnosis; glaucoma; glaucoma test; histology; human subject; morphometry; neuropathology; optical tomography; patient oriented research; retina; retinal ganglion; three dimensional imaging /topography; video recording system

DESCRIPTION (provided by applicant): Glaucoma is the second leading cause of blindness worldwide. In the United States, approximately 2.5 million Americans are affected by this potentially blinding eye disease. Optical coherence tomography is the only non-invasive imaging technique allowing high-resolution cross-sectional imaging of the human retina. Since glaucoma causes thinning of the retinal nerve fiber layer prior to initial loss of vision, optical coherence tomograhy (which can measure the nerve fiber layer thickness) could enable early detection of glaucoma prior to any permanent loss of vision. This earlier detection would enable earlier treatment to prevent permanent loss of vision. Since glaucoma also causes progressive nerve fiber layer thinning prior to further loss of vision, optical coherence tomography could enable earlier detection of glaucomatous disease progression prior to further permanent loss of vision, enabling more aggressive preventive treatment. Current clinical techniques only allow diagnosis of glaucomatous loss of vision after up to half of the retinal ganglion cells are permanently lost. The overall goal of this research is A) to develop a video rate Optical Coherence Tomography (OCT) system for 3 dimensional high resolution imaging of the human retina and the retinal nerve fiber layer (RNFL), B) to determine the resolution and reproducibility of in vivo retinal nerve fiber layer thickness determination with video rate OCT in normal and glaucoma subjects, C) to correlate in vivo human OCT images with histology of the same eye.

描述（由申请人提供）： 青光眼是全球失明的第二大主要原因。在美国，大约有250万美国人受到这种蒙蔽眼病的影响。光学相干断层扫描是唯一允许人视网膜的高分辨率横截面成像的非侵入性成像技术。由于青光眼在初始视力丧失之前会导致视网膜神经纤维层变薄，因此光学相干性tomograhy（可以测量神经纤维层的厚度）可以在任何永久视力丧失之前早期检测到青光眼。较早的检测将使早期的治疗能够防止永久视力丧失。由于青光眼在进一步丧失视力之前还会导致进行性神经纤维层变薄，因此光学相干断层扫描可以在进一步永久性视力丧失之前早期检测到胶状疾病进展，从而实现更具积极的预防治疗。当前的临床技术仅允许诊断出多达一半的视网膜神经节细胞后，视力丧失被诊断。 The overall goal of this research is A) to develop a video rate Optical Coherence Tomography (OCT) system for 3 dimensional high resolution imaging of the human retina and the retinal nerve fiber layer (RNFL), B) to determine the resolution and reproducibility of in vivo retinal nerve fiber layer thickness determination with video rate OCT in normal and glaucoma subjects, C) to correlate in vivo human OCT images with histology of the same eye.