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iMRI Methods for Cancer Diagnosis and Treatment

用于癌症诊断和治疗的 iMRI 方法

基本信息

批准号：
7114322
负责人：
Kim Butts-Pauly
金额：
$ 34.53万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7114322
关键词：
bioimaging /biomedical imaging biopsy clinical research diagnosis design /evaluation diagnosis quality /standard human subject liver imaging /visualization /scanning liver neoplasms magnetic resonance imaging method development neoplasm /cancer diagnosis neoplasm /cancer thermotherapy swine temperature thermography thermometry

项目摘要

DESCRIPTION (provided by applicant): Malignant neoplasms of the liver cause significant morbidity and mortality in the US. Fortunately, for patients with hepatocellular carcinoma or metastatic colorectal carcinoma that is limited to the liver, surgical treatment of the individual hepatic lesions can result in a favorable prognosis. However, surgery is limited to 10% of these patients, and for all others, treatment options are limited. Minimally invasive thermal ablation has the potential to provide a non-surgical treatment option. MRI can provide real-time visualization of treatment devices within the liver. MRI can also potentially ensure adequate heating of target tumor tissue and sparing of adjacent critical organs by providing real-time temperature imaging. This capability would enhance both the effectiveness and safety of thermal therapy. No other imaging modality is capable of providing in vivo temperature maps. Unfortunately, MRI is generally bypassed as a monitoring modality in favor of other modalities such as ultrasound and CT. This is because the promise of robust real-time thermometry for liver ablation has remained an elusive goal due to respiratory motion artifacts. At Stanford, we have been successful in developing MR temperature-mapping techniques suitable for use in minimally invasive treatment of stationary tissues such as the brain and the prostate. We now extend this work to the liver because of its great clinical importance. The major focus will be to develop MR methods that will ensure accurate and precise temperature imaging and to define the achieved accuracy and precision in animal studies. Specifically, we will improve the baseline phase correction with the use of a gated, navigated, multibaseline, volumetric imaging method. These improvements are the key to overcoming the barriers to the use of MR temperature imaging for guiding thermal therapies.

描述(由申请人提供)：在美国，肝脏恶性肿瘤会导致严重的发病率和死亡率。幸运的是，对于仅限于肝脏的肝细胞癌或转移性结直肠癌患者，个别肝脏病变的外科治疗可以获得良好的预后。然而，手术仅限于这些患者中的10%，而对于所有其他患者，治疗选择有限。微创热消融有可能提供一种非手术治疗方案。磁共振成像可以提供肝脏内治疗设备的实时可视化。MRI还可以通过提供实时温度成像，潜在地确保靶区肿瘤组织的充分加热和邻近关键器官的保留。这种能力将提高热疗的有效性和安全性。没有其他成像方式能够提供活体温度图。不幸的是，MRI作为一种监测手段通常被忽略，而倾向于其他方式，如超声波和CT。这是因为由于呼吸运动伪影，用于肝脏消融的强大的实时体温测量的前景仍然是一个难以实现的目标。在斯坦福大学，我们已经成功地开发出适用于脑和前列腺等静止组织的微创治疗的磁共振温度映射技术。我们现在将这项工作扩展到肝脏，因为它具有巨大的临床重要性。主要的重点将是开发磁共振方法，以确保准确和精确的温度成像，并确定在动物研究中实现的准确性和精密度。具体地说，我们将使用门控、导航、多基线、体积成像方法来改进基线相位校正。这些改进是克服使用磁共振温度成像指导热疗的障碍的关键。