Controlling peptide topology to access a new class of MRI contrast agents

控制肽拓扑以获得新型 MRI 造影剂

• 批准号: 2746274
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746274
• 关键词: Controlling; peptide; topology; access; new

This project will use topological design to access a new and highly novel class of MRI contrast agents (CAs). Peptide CAs based for the first time on Cu(II), will challenge the existing dogma that this paramagnetic metal is unsuitable for use in MRI CAs. This project will explore the relationship between topological peptide design (parallel vs antiparallel, oligomeric state, homo vs heteroassembly), Cu(II) binding and MRI CA performance, so as to develop an entirely new class of MRI CAs.

该项目将使用拓扑设计来获得一种新型的高度新颖的MRI造影剂（CA）。首次基于Cu（II）的肽CA将挑战这种顺磁性金属不适合用于MRI CA的现有教条。本项目将探索拓扑肽设计（平行与反平行，寡聚状态，同源与异源组装），Cu（II）结合和MRI CA性能之间的关系，从而开发出一种全新的MRI CA。