Controlling peptide topology to access a new class of MRI contrast agents

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This project will use topological design to access a new and highly novel class of MRI contrast agents (CAs). Peptide CAs based for the first time on Cu(II), will challenge the existing dogma that this paramagnetic metal is unsuitable for use in MRI CAs. This project will explore the relationship between topological peptide design (parallel vs antiparallel, oligomeric state, homo vs heteroassembly), Cu(II) binding and MRI CA performance, so as to develop an entirely new class of MRI CAs.