Function of Factor H-related protein-5, a novel human plasma complement protein found in glomerular immune deposits

H因子相关蛋白5的功能，一种在肾小球免疫沉积物中发现的新型人血浆补体蛋白

• 批准号: nhmrc : 204705
• 负责人: Prof Brendan Murphy
• 金额: $ 12.43万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-factor-h-immune-deposits/96082
• 关键词: Function; Factor; related; protein; novel

The Investigators have recently discovered a new protein which is present in human blood and is also seen in the diseased kidneys of patients with nephritis. The new protein is present in all types of nephritis that are caused by antibodies together with another part of the immune system, called the complement system, which is know to have an important role in causing tissue damage in immune diseases. The new protein is a part of the complement system but its exact function is not yet known. The protein is likely to be important in immune diseases because it is so commonly found in diseased kidneys and other organs with complement-associated disease. In this project we will conduct a series of experiments which will determine how the new protein works in the complement system and also how important the protein is in causing kidney damage in nephritis. Nephritis is the commonest cause of kidney failure in Australia and research directed towards the mechanism of kidney damage has the potential to produce new types of therapy. The complement system also has a major role in other inflammatory diseases and in body defense systems (such as protection against microbial attack). The complement system must be able to distinguish between foreign particles and the body's own tissue and this new protein may have a role in the appropriate regulation of complement to attack the right things in the body. Elucidation of the function of this protein may well assist, therefore, in developing therapies for a variety of inflammatory diseases and infectious diseases, in addition to nephritis.

研究人员最近发现了一种新的蛋白质，这种蛋白质存在于人类血液中，也见于肾炎患者的患病肾脏中。这种新的蛋白质存在于所有类型的肾炎中，这些肾炎是由抗体和免疫系统的另一部分（称为补体系统）引起的，已知补体系统在免疫疾病中引起组织损伤方面具有重要作用。这种新蛋白是补体系统的一部分，但其确切功能尚不清楚。这种蛋白质可能在免疫疾病中很重要，因为它在患有补体相关疾病的肾脏和其他器官中很常见。在这个项目中，我们将进行一系列的实验，以确定新蛋白质如何在补体系统中发挥作用，以及该蛋白质在肾炎中引起肾损伤的重要性。肾炎是澳大利亚最常见的肾衰竭原因，针对肾损伤机制的研究有可能产生新的治疗方法。补体系统在其他炎症性疾病和身体防御系统（如防止微生物攻击）中也有重要作用。补体系统必须能够区分外来颗粒和身体自身的组织，这种新的蛋白质可能在适当调节补体以攻击体内正确的东西方面发挥作用。因此，阐明这种蛋白质的功能可能很好地有助于开发除肾炎外的多种炎症性疾病和传染病的疗法。