Optical Spectroscopy for Management of Cancer Treatment

描述(由申请人提供)：该团队的目标是将光学药代动力学(OP)和弹性散射光谱(ESS)方法应用于光动力疗法(PDT)在癌症和其他病理治疗中的临床应用。OP将用于监测PDT制剂的局部组织浓度和生物分布，提供关于剂量和最佳激活时间的患者特定信息。ESS将被用作一种辅助工具，通过检测组织光学性质的变化来跟踪组织对治疗的反应。短期目标是检测和解决临床实施的任何限制，证明这些是临床上“友好的”模式，并生成将在临床治疗期间实时提供测量结果的计算/数值工具。理想的光动力疗法的实施需要提供适当的药物剂量和适当的光“剂量”，这反过来又需要了解组织的光学性质和有关组织中药物浓度的知识。体内测量将提供有关患者对药物摄取的可变性的信息，从而使PDT的个人剂量测定成为可能。此外，药物特定部位的时间史尤其重要，因为光活化应在肿瘤内药物浓度与周围组织的药物浓度之比达到最大时进行。初级项目涉及动物和临床研究，以回答一系列问题，旨在验证光谱方法的能力和敏感性，并评估影响临床实用和保健意义的方法的那些方面的影响。技术支持核心-为所有项目提供工具和数学工具，并促进数据分析。行政核心提供了团队的上层建筑，特别是促进了团队内部和网络所有团队之间的沟通和信息共享。

DESCRIPTION (provided by applicant): The goal of this Team is the clinical application of the methods of Optical Pharmacokinetics (OP) and Elastic Scattering Spectroscopy (ESS) for the management of photodynamic therapy (PDT) in the treatment of cancer and other pathologies. OP will be used to monitor local tissue concentrations andbiodistribution of PDT agents, providing patient-specific information on dosage and optimal time foractivation. ESS will be used as an adjunct to follow the response of tissues to treatment by sensingchanges in the tissue optical properties. The short-term objectives are to detect and resolve any limitations for clinical implementation, to demonstrate that these are clinically "friendly" modalities, and to generate the computational/numerical tools that will provide the measured results in real time during clinical treatment. The ideal implementation of PDT requires delivery of both the proper drug dosage and the proper light "dosage", which in turn requires understanding of the optical properties of the tissue and knowledge of drug concentration in the tissue of interest. In vivo measurements would provide information on patient-patient variability in the uptake of the drug and, therefore, make possible individual dosimetry for PDT. In addition, the site-specific time history of the drug is especially important because the photoactivation should be done when the ratio of drug concentration in the tumor to surrounding tissue is at a maximum. The Primary Projects address both animal and clinical studies to answer a series of questions aimed at validating the capabilities and sensitivities of the spectroscopic methods and assessing the implications of those aspects of the methods that impact clinical utility and health-care significance. The Technical Support Core-provides-the-instrumentation-and the mathematical tools to all Projects and facilitates the data analysis. The Administrative Core provides the superstructure of the Team, especially to facilitate communication and information sharing, both within this Team and among all the Teams of the Network.