Optical Spectroscopy for Management of Cancer Treatment

描述（由申请人提供）：该团队的目标是将光学药代动力学（OP）和弹性散射光谱（ESS）方法用于管理光动力学疗法（PDT）治疗癌症和其他疾病的临床应用。OP将用于监测PDT药物的局部组织浓度和生物分布，提供有关剂量和最佳激活时间的患者特定信息。ESS将作为一种辅助手段，通过感知组织光学特性的变化来跟踪组织对治疗的反应。短期目标是检测和解决临床实施的任何限制，以证明这些是临床“友好”的模式，并生成计算/数值工具，将在临床治疗期间提供真实的测量结果。 PDT的理想实施方式需要递送适当的药物剂量和适当的光“剂量”，这又需要理解组织的光学性质和了解感兴趣组织中的药物浓度。体内测量将提供关于药物摄取的患者-患者变异性的信息，因此，使PDT的个体剂量测定成为可能。此外，药物的位点特异性时间历程是特别重要的，因为光活化应该在肿瘤与周围组织中的药物浓度的比率处于最大值时进行。 主要项目涉及动物和临床研究，以回答一系列问题，旨在验证光谱方法的能力和灵敏度，并评估影响临床实用性和医疗保健意义的方法的影响。技术支持核心为所有项目提供仪器和数学工具，并促进数据分析。行政核心为该小组提供上层结构，特别是促进该小组内部和网络所有小组之间的沟通和信息共享。

DESCRIPTION (provided by applicant): The goal of this Team is the clinical application of the methods of Optical Pharmacokinetics (OP) and Elastic Scattering Spectroscopy (ESS) for the management of photodynamic therapy (PDT) in the treatment of cancer and other pathologies. OP will be used to monitor local tissue concentrations andbiodistribution of PDT agents, providing patient-specific information on dosage and optimal time foractivation. ESS will be used as an adjunct to follow the response of tissues to treatment by sensingchanges in the tissue optical properties. The short-term objectives are to detect and resolve any limitations for clinical implementation, to demonstrate that these are clinically "friendly" modalities, and to generate the computational/numerical tools that will provide the measured results in real time during clinical treatment. The ideal implementation of PDT requires delivery of both the proper drug dosage and the proper light "dosage", which in turn requires understanding of the optical properties of the tissue and knowledge of drug concentration in the tissue of interest. In vivo measurements would provide information on patient-patient variability in the uptake of the drug and, therefore, make possible individual dosimetry for PDT. In addition, the site-specific time history of the drug is especially important because the photoactivation should be done when the ratio of drug concentration in the tumor to surrounding tissue is at a maximum. The Primary Projects address both animal and clinical studies to answer a series of questions aimed at validating the capabilities and sensitivities of the spectroscopic methods and assessing the implications of those aspects of the methods that impact clinical utility and health-care significance. The Technical Support Core-provides-the-instrumentation-and the mathematical tools to all Projects and facilitates the data analysis. The Administrative Core provides the superstructure of the Team, especially to facilitate communication and information sharing, both within this Team and among all the Teams of the Network.