Training Program in Quantitative Biology andPhysiology

描述(由申请人提供)：本提案寻求未来五年的支持，以继续我们已建立的名为定量生物学和生理学(QBP)的培训计划。我们的使命是培养具有以下能力的博士研究科学家：(1)对分子生物学、细胞生物学和生理学的基本原理有定量的理解；(2)将现代和定量驱动的实验方法与生物学和生理学相结合的能力；(3)通过生物和生理系统的多个尺度(分子-细胞-组织-器官)的集成来综合基于机械和结构的建模技能的能力；以及(4)通过整合生物或生理系统或过程的多个尺度(分子-细胞-组织-器官)来评估紧急特性和行为的能力。我们更新的具体目标是：保持和加强核心的跨学科导师队伍，主要来自生物医学工程，但也包括生物、物理、化学、数学、机械工程、电气和计算机工程以及BU医学院的系。提供包括多个长度尺度的定量分子生物学、细胞生物学和生理学的严格培训的课程。提供实验室轮换，以确保接触到与生物学和生理学多个尺度的问题有关的定量和系统/动力学研究技术。为研究生提供进行跨学科的、定量的、综合的、与实验和/或临床数据相联系的论文研究的机会。通过互动活动，包括杂志俱乐部、年度QBP研讨会和每月晚宴，加强QBP计划和社区的独特身份和影响力。BME部门继续吸引高素质的实习生，他们组织起来创造了一个赋权的身份。这些学员还继续开展促进QBP计划主题的活动，以丰富整个机构。我们扩大了培训指导员队伍，提高了整个部门的质量，并根据经验和反馈修改了我们的管理方法。我们期待着在下一个赠款周期中有机会继续保持这一势头。

DESCRIPTION (provided by applicant): This proposal seeks the next five years of support to continue our established training program entitled Quantitative Biology and Physiology (QBP). Our mission is to train PhD research scientists who have: (1) a quantitatively based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern and quantitatively driven experimental methods with biology and physiology; (3) the ability to synthesize mechanistically and structurally based modeling skills with biological and physiological systems; and (4) the capacity to assess emergent properties and behaviors via integration across multiple scales (molecular-cellular-tissue-organ) of a biological or physiological system or process. The specific objectives of our renewal are: To maintain and strengthen a core interdisciplinary faculty of mentors primarily from Biomedical Engineering, but also including Biology, Physics, Chemistry, Mathematics, Mechanical Engineering, Electrical & Computer Engineering and departments at the BU School of Medicine. To provide a program curriculum that includes rigorous training in quantitative molecular biology, cell biology, and physiology at multiple length scales. To provide laboratory rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at multiple scales of biology and physiology. To provide graduate trainees with the opportunity to conduct thesis research that is interdisciplinary, quantitative, integrativ, and linked to experimental and/or clinical data. To strengthen the unique identity and impact of the QBP program and community via interactive components, including a Journal Club, a yearly QBP Symposium, and Monthly Dinners. The BME department continues to attract high caliber trainees who have organized to create an empowering identity. These trainees also sustain activities that foster the themes of the QBP program so as to enrich the entire institution. We have expanded our training mentor pool, improved the quality of the department as a whole, and revised our administrative approach based on experience and feedback. We look forward to the opportunity to continue this momentum during the next grant cycle.