Function of sulfotransferase SULT4A1 - transcriptional and post-transcriptional regulation

磺基转移酶 SULT4A1 的功能 - 转录和转录后调控

• 批准号: nhmrc : 511175
• 负责人: Prof Rodney Minchin
• 金额: $ 20.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-sulfotransferase-sult4a1-transcriptional-regulation/78438
• 关键词: Function; sulfotransferase; SULT4A1; transcriptional; post

Our understanding of how important proteins work is critical to devising modern approaches for disease treatment. This project looks specifically at a protein sulfotransferase 4A1 linked with schizophrenia, and may be involved in other neuronal disorders. The plan is to characterise how the protein functions and what might be the implications of abnormal regulation. Through a series of intricate experiments, the molecular and cellular properties of the protein will be more clearly defined.

我们对蛋白质如何发挥重要作用的理解，对于设计现代疾病治疗方法至关重要。这个项目专门研究了一种与精神分裂症有关的蛋白磺基转移酶4A1，并可能与其他神经元疾病有关。该计划是为了描述这种蛋白质的功能，以及异常调控可能带来的影响。通过一系列错综复杂的实验，蛋白质的分子和细胞性质将得到更清晰的定义。