Targeting CD4-positive cells for anti-HIV gene therapy

针对 CD4 阳性细胞进行抗 HIV 基因治疗

• 批准号: nhmrc : 110211
• 负责人: Prof Rodney Minchin
• 金额: $ 23.78万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-cd4-positive-gene-therapy/96816
• 关键词: Targeting; CD4; positive; cells; anti

Treatment of HIV early following infection is thought to be important for maximising the quality of life of patients. Conventional therapy has had some success in early intervention but resistance invariably develops. This application proposes to develop a gene therapy approach to elimiate HIV infected cells by introducing a suicide gene into those cells that harbor the virus. The advantage of this approach is the limited toxicity that is associated with gene therapies as well as the ability to target specific cell-types. It is proposed to genetically modify a strain of adenovirus to introduce a gene that will kill cells that it infects that also contain HIV. This is a novel approach and potentially may be an important treatment in the future. Anti-HIV gene therapy may also be useful in addition to the more conventional treatments.

在感染后早期治疗艾滋病毒被认为对最大限度地提高患者的生活质量很重要。常规治疗在早期干预方面取得了一些成功，但耐药性总是会出现。本申请提出开发一种基因治疗方法，通过将自杀基因引入那些携带病毒的细胞中来消除HIV感染的细胞。这种方法的优点是与基因疗法相关的有限毒性以及靶向特定细胞类型的能力。有人建议对一种腺病毒株进行遗传修饰，以引入一种基因，这种基因将杀死它感染的也含有艾滋病毒的细胞。这是一种新的方法，可能是未来的一种重要治疗方法。抗HIV基因疗法也可能是有用的，除了更传统的治疗。