Human arylamine N-acetyltransferase regulation and function - effect of genetic poymorphisms.

人芳胺 N-乙酰转移酶的调节和功能 - 遗传多态性的影响。

• 批准号: nhmrc : 212066
• 负责人: Prof Rodney Minchin
• 金额: $ 28.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/human-arylamine-n-genetic-poymorphisms/99614
• 关键词: Human; arylamine; acetyltransferase; regulation; function

How we handle chemicals that enter our bodies depends on a series of enzymes that are responsible for breaking down the chemicals and eliminating them. The activity of many of these enzymes varies between individuals so our responses to chemicals and drugs is different for each individual. Some of the enzymes vary because of inherited mutations, but others vary because of the diets we eat and the environment in which we live. This project will investigate a major enzyme called acetlytransferase that has been implicated as a risk factor in diseases such as cancer, asthma, liver cirrhossis and adverse drug reactions. We plan to look at the enzyme in cells and determine what environmental factors contribute to its variation between individuals, and how this impacts on the genetic mutations that have been found in its gene. From these studies, we will have a much better undersanding of how different people metabolise foreign chemicals, and should be able to predict those most at risk of certain diseases.

我们如何处理进入我们身体的化学物质取决于一系列负责分解和消除化学物质的酶。这些酶中的许多活性因个体而异，因此我们对化学物质和药物的反应因人而异。有些酶因为遗传突变而不同，但另一些则因我们的饮食和我们生活的环境而不同。这个项目将研究一种名为乙酰转移酶的主要酶，它被认为是癌症、哮喘、肝硬变和药物不良反应等疾病的风险因素。我们计划研究细胞中的这种酶，并确定是什么环境因素导致了它在个体之间的差异，以及这对已在其基因中发现的基因突变有何影响。从这些研究中，我们将对不同的人如何代谢外来化学物质有更好的了解，并应该能够预测哪些人最有可能患上某些疾病。